{"id":"W4368363014","doi":"10.21203/rs.3.rs-2879768/v1","title":"O. volvulus microfilariae in the anterior chambers of the eye and ocular adverse events after a single dose of 8 mg moxidectin or 150 µg/kg ivermectin: Results of a randomized double-blind Phase 3 trial in the Democratic Republic of the Congo, Ghana and Liberia","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"","keywords":"Ivermectin; Moxidectin; Medicine; Onchocerciasis; Adverse effect; Anthelmintic; Albendazole; Surgery; Anesthesia; Internal medicine; Veterinary medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002293244,0.0008060195,0.001318191,0.0002448642,0.0004182915,0.0005956594,0.0004852784,0.0008543701,0.003645235],"category_scores_gemma":[0.001787134,0.0004285513,0.001471974,0.0003359315,0.0009223335,0.0005294547,0.0002713413,0.001376407,0.0003133779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007553624,"about_ca_system_score_gemma":0.0008743302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001003354,"about_ca_topic_score_gemma":0.002429471,"domain_scores_codex":[0.9990296,0.0005804804,0.000068324,0.0001310827,0.00008058223,0.0001097881],"domain_scores_gemma":[0.9981647,0.0005753256,0.0006329735,0.0000899849,0.0001144463,0.0004225348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9067141,0.03617914,0.01470071,0.001162614,0.001654954,0.0001206935,0.0002212729,0.0004237435,0.01195745,0.00008743598,0.0008426164,0.0259353],"study_design_scores_gemma":[0.6296703,0.3188677,0.04564335,0.00008427791,0.001335562,0.0001483943,0.0001251504,0.0005278146,0.002457991,0.0001124331,0.0009962365,0.00003069309],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957914,0.001508621,0.0001819941,0.0001163974,0.00006394189,0.001569334,0.0003475494,0.00001309208,0.0004075667],"genre_scores_gemma":[0.9962738,0.0006739629,0.0004493249,0.000204431,0.00006579455,0.001593922,0.0002485064,0.000003560732,0.0004867188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003645235,"threshold_uncertainty_score":0.01219457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09618389819553719,"score_gpt":0.4305946995972456,"score_spread":0.3344108014017084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}