{"id":"W4368365214","doi":"10.1038/s41467-023-38165-6","title":"Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; National Institute on Alcohol Abuse and Alcoholism; Lee Kong Chian School of Medicine, Nanyang Technological University; U.S. Department of Health and Human Services; National Institutes of Health; Azrieli Foundation; Office of Extramural Research, National Institutes of Health; Nanyang Technological University","keywords":"Autophagy; Steatosis; Fatty liver; Mitophagy; Lysosome; Endocytosis; Flux (metallurgy); Mitochondrion; Phospholipidosis; Cell biology; Nonalcoholic fatty liver disease; Chemistry; Biochemistry; Biology; Endocrinology; Internal medicine; Disease; Medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001917909,0.0002715774,0.000370605,0.0002125061,0.0001218239,0.0002133484,0.0001842863,0.0003477275,0.0007836255],"category_scores_gemma":[0.0001286841,0.0001002515,0.0002755336,0.0001018912,0.0001946536,0.0001895278,0.0002373457,0.0004712267,0.0001741885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400338,"about_ca_system_score_gemma":0.0001968737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004131162,"about_ca_topic_score_gemma":0.0007586443,"domain_scores_codex":[0.9999164,0.0000158335,0.000009539224,0.00001301648,0.00002197991,0.00002325415],"domain_scores_gemma":[0.9999251,0.000008472372,0.00002189274,0.00001102862,0.00001005984,0.00002344136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006241463,0.0001343168,0.0001746649,0.000125983,0.00001657322,0.0001167231,0.0000163258,0.0001643811,0.9914389,0.0001376983,0.0001099876,0.006940285],"study_design_scores_gemma":[0.0001069131,0.00167532,0.003980186,0.00002268843,0.00003523869,0.0004158352,0.00003970988,0.0009972046,0.9876276,0.0001695456,0.004919823,0.000009973284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890082,0.003982644,0.004438773,0.0001858974,0.00008940261,0.00004984359,0.0001669746,0.0002377284,0.001840659],"genre_scores_gemma":[0.9937033,0.001632551,0.002306919,0.0001038825,0.0000158564,0.00003081339,0.0002298822,0.00002956943,0.001947164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007836255,"threshold_uncertainty_score":0.002621472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02984380649343969,"score_gpt":0.3271559692293822,"score_spread":0.2973121627359425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}