{"id":"W4368370348","doi":"10.1101/2023.05.03.539243","title":"Cross-feeding affects the target of resistance evolution to an antifungal drug","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal; PROTEO","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Genome Canada","keywords":"Biology; Drug resistance; Mutant; Cytosine deaminase; Antifungal drug; Genetics; Fluconazole; Saccharomyces cerevisiae; Computational biology; Gene; Microbiology; Antifungal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253229,0.0004390412,0.0003315295,0.0004867149,0.0001957803,0.0004879343,0.0003450066,0.0005889623,0.001692094],"category_scores_gemma":[0.000353003,0.000198693,0.0003762673,0.0003264059,0.0002070286,0.0002073158,0.0005635265,0.0007671936,0.0003185442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004061967,"about_ca_system_score_gemma":0.0001555533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007050713,"about_ca_topic_score_gemma":0.000855791,"domain_scores_codex":[0.9996318,0.00005917212,0.00004144533,0.0001134974,0.00009245345,0.00006164116],"domain_scores_gemma":[0.9996307,0.00009758503,0.0001037296,0.00005334139,0.00005266447,0.00006202504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003976561,0.00003285455,0.0006967601,0.00001282725,0.000008480495,0.00004576475,0.00001071177,0.00005464394,0.9979121,0.00003623806,0.00001322482,0.0011367],"study_design_scores_gemma":[0.000007862416,0.0004229151,0.05671812,0.00001323841,0.00005098105,0.0008719959,0.00009255735,0.002042912,0.9373831,0.00007313013,0.002306177,0.0000171316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957374,0.0003678795,0.002316843,0.00004522063,0.00001397721,0.00002293793,0.0004132857,0.00006969102,0.001012622],"genre_scores_gemma":[0.9966312,0.0001383123,0.001609656,0.00007094081,0.00000292318,0.00001804847,0.0005732407,0.00004937235,0.000906245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692094,"threshold_uncertainty_score":0.005660594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0205428306499415,"score_gpt":0.2773008864658867,"score_spread":0.2567580558159452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}