{"id":"W4368370371","doi":"10.26434/chemrxiv-2023-fvrjl","title":"Mapping peptide-protein interactions by amine-reactive cleavable photoaffinity reagents","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; McGill University","funders":"Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Fonds Wetenschappelijk Onderzoek; Bundesministerium für Bildung und Forschung","keywords":"Photoaffinity labeling; Chemistry; Peptide; Binding site; Combinatorial chemistry; Tandem mass spectrometry; Drug discovery; Cleavage (geology); Small molecule; Target protein; Biochemistry; Stereochemistry; Mass spectrometry; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003278771,0.0004526888,0.0002353002,0.0003888236,0.0002459089,0.0004642314,0.0004472133,0.0005311372,0.002517803],"category_scores_gemma":[0.0003849339,0.0002985137,0.0002803288,0.0002676897,0.0003452764,0.0003541153,0.0003176738,0.001102768,0.001351656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004588593,"about_ca_system_score_gemma":0.0002528353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006220467,"about_ca_topic_score_gemma":0.001172222,"domain_scores_codex":[0.9997689,0.00003878774,0.00001168397,0.00006715728,0.00007628693,0.00003716709],"domain_scores_gemma":[0.9998013,0.00008423314,0.00004398045,0.00003106644,0.00002024918,0.00001913245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001764872,0.000005749166,0.00004771422,0.00002533131,0.000003704804,0.00002852928,0.000008604469,0.00006131028,0.998664,0.0001703049,0.00003873091,0.0009284637],"study_design_scores_gemma":[0.000002835256,0.00001883426,0.0003273478,0.000001642743,0.000003395643,0.00006414134,0.000006267202,0.000418176,0.9978092,0.00006638365,0.001279445,0.000002265261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.786787,0.004510142,0.1991794,0.000472532,0.0001071771,0.0001925261,0.0009186605,0.0007545277,0.007078019],"genre_scores_gemma":[0.8720366,0.004252648,0.1082537,0.0003749071,0.00004478246,0.0002541703,0.001423402,0.0002826427,0.01307718],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002517803,"threshold_uncertainty_score":0.008422852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899581788985837,"score_gpt":0.2695247892604705,"score_spread":0.2405289713706121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}