{"id":"W4368373774","doi":"10.1016/j.ymthe.2023.04.021","title":"A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Akebia Therapeutics; Canadian Institute of Steel Construction; Children’s Hospital of Wisconsin Research Institute; Seattle Children's Research Institute; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"In vivo; Cell biology; Biology; T-cell receptor; FOXP3; CD19; Chimeric antigen receptor; In vitro; T cell; Cancer research; Immunology; Antigen; Immune system; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005820417,0.0001508609,0.0003760894,0.0004138595,0.00001779883,0.00001079247,0.00007333264,0.0001290453,0.0002089284],"category_scores_gemma":[0.00005027666,0.0001501529,0.00009171962,0.0008483264,0.00004150173,0.00002792928,0.00001632586,0.0002176977,0.000003257448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001091073,"about_ca_system_score_gemma":0.00004992819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006963834,"about_ca_topic_score_gemma":0.000007382531,"domain_scores_codex":[0.9987821,0.00009937433,0.0002496495,0.0003143997,0.000234961,0.0003195206],"domain_scores_gemma":[0.9994262,0.0002099061,0.00004286974,0.0001596294,0.00009094695,0.00007039505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003171478,0.0001328914,0.0002261821,0.00009711722,0.00008529142,0.00001231367,0.0005409233,0.0001894817,0.9850263,0.000004638558,0.00008125265,0.01043211],"study_design_scores_gemma":[0.005124017,0.0004782526,0.0006247297,0.00006595385,0.000006615328,0.0000031641,0.0000497494,0.005088665,0.986113,0.00009006605,0.002233898,0.0001218732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969405,0.0001715338,0.0006734879,0.000198781,0.00003287691,0.001852023,0.00001639939,0.00004409987,0.00007027511],"genre_scores_gemma":[0.9974371,0.0002271306,0.001550341,0.0001296085,0.00003858143,0.0003074687,0.00004157308,0.00005433611,0.0002138926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01031024,"threshold_uncertainty_score":0.6123059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374530388069387,"score_gpt":0.3002096828997834,"score_spread":0.2764643790190895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}