{"id":"W4372201905","doi":"10.1016/j.ijrobp.2023.04.032","title":"Salvage Radiation Therapy After Radical Prostatectomy: Analysis of Toxicity by Dose-Fractionation in the RADICALS-RT Trial","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Centre Hospitalier de l’Université de Montréal; Queen's University","funders":"Institute of Cancer Research; Medical Research Council; Astellas Pharma; National Institute for Health and Care Research; Cancer Research UK; Clovis Oncology; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Sanofi; Canadian Cancer Society; Royal Marsden NHS Foundation Trust; Amgen; Pfizer; Myriad Genetics; AstraZeneca; UK Research and Innovation; Eli Lilly and Company","keywords":"Medicine; Prostate cancer; Toxicity; Prostatectomy; Urology; Radiation therapy; Dose fractionation; Internal medicine; Nuclear medicine; Surgery; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002217268,0.001470429,0.003530172,0.0002966037,0.0003150053,0.001008966,0.001008415,0.0007181858,0.00259947],"category_scores_gemma":[0.001751529,0.0003076439,0.004064297,0.0004656416,0.0007818263,0.0007268878,0.0006255315,0.002470427,0.0002979565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009196128,"about_ca_system_score_gemma":0.001040271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228531,"about_ca_topic_score_gemma":0.003197842,"domain_scores_codex":[0.9988881,0.0006656503,0.00005193889,0.0001804163,0.00007910479,0.0001349176],"domain_scores_gemma":[0.9988297,0.0003351919,0.0003301279,0.0001790737,0.00003705858,0.0002888586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9324529,0.002875711,0.009584809,0.0005280163,0.008570722,0.00008872986,0.0001788185,0.003515694,0.006289222,0.0002799118,0.001156942,0.03447843],"study_design_scores_gemma":[0.5057634,0.32509,0.1336389,0.0002847292,0.01983949,0.0004087249,0.0002865598,0.00462631,0.003186266,0.00288718,0.003858297,0.0001301394],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994727,0.00362081,0.000247926,0.0001878927,0.00009279586,0.0001300189,0.0004572039,0.00001790046,0.000518531],"genre_scores_gemma":[0.996061,0.001260025,0.0002783902,0.0002731398,0.0001509854,0.0001610589,0.000755892,0.00001957686,0.001039933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003530172,"threshold_uncertainty_score":0.01172614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516615028139788,"score_gpt":0.3622089268677945,"score_spread":0.3370427765863966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}