{"id":"W4372214904","doi":"10.1016/s0140-6736(23)00520-2","title":"Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in individuals with basal-bolus insulin-treated type 2 diabetes (ONWARDS 4): a phase 3a, randomised, open-label, multicentre, treat-to-target, non-inferiority trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Management and Research","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Novo Nordisk","keywords":"Medicine; Insulin glargine; Insulin; Basal insulin; Diabetes mellitus; Type 2 diabetes; Open label; Bolus (digestion); Internal medicine; Type 1 diabetes; Insulin degludec; Endocrinology; Pediatrics; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129709,0.001869463,0.00337332,0.0003521208,0.0003289328,0.00140674,0.0009451281,0.001980237,0.008823686],"category_scores_gemma":[0.001843227,0.0005384768,0.00259648,0.0003817522,0.001061349,0.001269941,0.0004710767,0.004478835,0.001325237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007328716,"about_ca_system_score_gemma":0.0006854479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001408821,"about_ca_topic_score_gemma":0.002066619,"domain_scores_codex":[0.9994887,0.0002229638,0.00002416816,0.0001075047,0.00003202772,0.0001245054],"domain_scores_gemma":[0.9992143,0.0003034481,0.0001324999,0.00008070688,0.00003427685,0.0002347655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9798252,0.003197807,0.0003606616,0.0003122349,0.0006399103,0.0000267641,0.00004546842,0.0002084224,0.00124076,0.00007576383,0.0005514137,0.01351557],"study_design_scores_gemma":[0.9627018,0.03392971,0.001731324,0.00004155481,0.0004630382,0.00002642846,0.000031516,0.0003469473,0.0001871109,0.0002521067,0.0002719759,0.00001647075],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991954,0.00274472,0.0004298967,0.0006705524,0.0006183338,0.0007700402,0.000531749,0.0001298575,0.002150889],"genre_scores_gemma":[0.9900709,0.001601776,0.001312896,0.001533828,0.0004026571,0.001072565,0.0006954301,0.00004363631,0.003266364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008823686,"threshold_uncertainty_score":0.02951819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07022276302367764,"score_gpt":0.3743919670718936,"score_spread":0.304169204048216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}