{"id":"W4372214904","doi":"10.1016/s0140-6736(23)00520-2","title":"Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in individuals with basal-bolus insulin-treated type 2 diabetes (ONWARDS 4): a phase 3a, randomised, open-label, multicentre, treat-to-target, non-inferiority trial","year":2023,"lang":"en","type":"article","venue":"The Lancet","topic":"Diabetes Management and Research","field":"Medicine","cited_by":135,"is_retracted":false,"has_abstract":false,"ca_institutions":"LMC Diabetes & Endocrinology (Canada)","funders":"Novo Nordisk","keywords":"Medicine; Insulin glargine; Insulin; Basal insulin; Diabetes mellitus; Type 2 diabetes; Open label; Bolus (digestion); Internal medicine; Type 1 diabetes; Insulin degludec; Endocrinology; Pediatrics; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003268013,0.0006356703,0.001979145,0.0007546969,0.000309777,0.0004094176,0.001455146,0.0002141941,0.0002076462],"category_scores_gemma":[0.001947866,0.0004252018,0.000110689,0.004009629,0.0001196695,0.0003469014,0.001002769,0.0009419103,0.000874423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003653647,"about_ca_system_score_gemma":0.0005541505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000495277,"about_ca_topic_score_gemma":0.0002792065,"domain_scores_codex":[0.9948209,0.0005084518,0.0008752583,0.0009699343,0.001149117,0.001676323],"domain_scores_gemma":[0.996565,0.000976465,0.0002326305,0.001354244,0.0002724818,0.0005992142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.830833,0.005205867,0.03701394,0.0004556527,0.001549971,0.0006325186,0.005307353,0.0007188744,0.00427475,0.0000489055,0.02758206,0.08637708],"study_design_scores_gemma":[0.9183423,0.008106317,0.03317757,0.0008116606,0.0004398264,0.00000106774,0.0004419254,0.008939494,0.001883442,0.00007149734,0.02699844,0.0007864814],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769839,0.0004492708,0.00003042415,0.008501234,0.0006037607,0.008398066,0.0001711564,0.0003062676,0.004555885],"genre_scores_gemma":[0.9894666,0.0004631616,0.001897164,0.001835283,0.001530112,0.0008435028,0.0004697611,0.0001516542,0.003342755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08750924,"threshold_uncertainty_score":0.9999035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07022276302367764,"score_gpt":0.3743919670718936,"score_spread":0.304169204048216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}