{"id":"W4372250795","doi":"10.1182/blood.2022018651","title":"A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Universität Ulm; Deutsche Forschungsgemeinschaft","keywords":"Biology; Myeloid leukemia; Haematopoiesis; Stem cell; Progenitor cell; Gene; RNA; Myeloid; Cell biology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001446909,0.00006369659,0.0001150604,0.00001781823,0.00004657469,0.00001185257,0.00007697788,0.00006133881,0.00007896028],"category_scores_gemma":[0.00003710932,0.00002723339,0.00003465588,0.0003438439,0.00003343535,0.00002840308,0.00006202744,0.0001000227,0.00002818667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000012889,"about_ca_system_score_gemma":0.00001834463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004921408,"about_ca_topic_score_gemma":0.001352062,"domain_scores_codex":[0.9994463,0.0000279009,0.0001652779,0.000148911,0.00007365296,0.0001379311],"domain_scores_gemma":[0.9997758,0.00009693489,0.00003834063,0.00002836358,0.00001911981,0.00004148189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001868546,0.0002524186,0.2204977,0.00002691959,0.00002186128,0.000005086052,0.0002139973,0.00000511687,0.7732148,0.001655471,0.00006268018,0.004025214],"study_design_scores_gemma":[0.0003422444,0.0001841384,0.9924847,0.00001810462,0.00001864881,0.000005083317,0.0001874987,0.000188908,0.002092639,0.004350842,0.00006120036,0.00006602622],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989786,0.00003795249,0.000002159554,0.0004601336,0.00003657772,0.0001160103,0.00001751109,0.00002391553,0.00032715],"genre_scores_gemma":[0.9997019,0.00005301785,0.00004144868,0.00003716955,0.00006643678,0.00001300777,0.00002433927,5.380566e-7,0.00006219841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.771987,"threshold_uncertainty_score":0.1110545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619515162577291,"score_gpt":0.2084915697663374,"score_spread":0.1922964181405645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}