{"id":"W4372250795","doi":"10.1182/blood.2022018651","title":"A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research; Universität Ulm; Deutsche Forschungsgemeinschaft","keywords":"Biology; Myeloid leukemia; Haematopoiesis; Stem cell; Progenitor cell; Gene; RNA; Myeloid; Cell biology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009014318,0.0002316095,0.0001614633,0.0003099514,0.0001580848,0.0002740724,0.0002149712,0.0001276424,0.001954761],"category_scores_gemma":[0.0001609657,0.00008852356,0.0001277525,0.0001764506,0.000226216,0.0001227591,0.0001948468,0.0003527364,0.0004645324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003135626,"about_ca_system_score_gemma":0.000209496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004212047,"about_ca_topic_score_gemma":0.0006851625,"domain_scores_codex":[0.9999028,0.00001306289,0.000006472461,0.00002314471,0.00003243628,0.00002207972],"domain_scores_gemma":[0.9998974,0.00001442317,0.00002580348,0.000019288,0.00001009009,0.0000330625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006608995,0.00001146373,0.0004211842,0.000008771202,0.000003121795,0.00004351451,0.000003983351,0.00003293176,0.997547,0.0001268099,0.0000325108,0.001702584],"study_design_scores_gemma":[0.00001462846,0.0001154204,0.01131384,0.000001597037,0.00001206408,0.0004357788,0.00001406288,0.0007588127,0.9831134,0.0001032537,0.004114505,0.00000261518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932132,0.0009723482,0.003336282,0.00008967875,0.00001466253,0.00001242672,0.000416571,0.0002135617,0.001731321],"genre_scores_gemma":[0.9952934,0.0002370713,0.001207501,0.0000232099,0.00000665264,0.00001196837,0.0005734352,0.00002399,0.002622742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001954761,"threshold_uncertainty_score":0.006539345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01619515162577291,"score_gpt":0.2084915697663374,"score_spread":0.1922964181405645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}