{"id":"W4372279715","doi":"10.1016/j.jaip.2023.02.029","title":"Have we reached our final destination with biologics in severe uncontrolled asthma?","year":2023,"lang":"en","type":"letter","venue":"The Journal of Allergy and Clinical Immunology In Practice","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Sanofi Genzyme; Genentech; Food Allergy Canada; Bausch Health; Public Health Agency; Glenmark Pharmaceuticals; Allergy Therapeutics; Mylan; LEO Pharma; Public Health Agency of Canada; Covis Pharma; Queen Mary University of London; University of Dundee; Aimmune Therapeutics; AstraZeneca; CSL Behring; Sanofi; Regeneron Pharmaceuticals; Institute for Health Metrics and Evaluation; Pfizer; American Thoracic Society; Teva Pharmaceutical Industries; European Respiratory Society","keywords":"Thymic stromal lymphopoietin; Medicine; Asthma; Scopus; Allergy; Exacerbation; Immunology; Internal medicine; Pediatrics; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002940343,0.0005821549,0.001297854,0.0005927967,0.004935139,0.004336558,0.001201256,0.04467987,0.007594214],"category_scores_gemma":[0.02536048,0.0004682419,0.001165449,0.0006774534,0.003436131,0.004849941,0.001627252,0.0393023,0.00438329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003959407,"about_ca_system_score_gemma":0.005078572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006511388,"about_ca_topic_score_gemma":0.01082653,"domain_scores_codex":[0.9969682,0.001104535,0.0003526098,0.0002357611,0.000693253,0.0006456808],"domain_scores_gemma":[0.9927549,0.002676446,0.0005287345,0.0001979062,0.001080314,0.002761729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002031374,0.0001254043,0.003864573,0.0001122657,0.00005973971,0.01314195,0.0004146706,0.0001620153,0.000272679,0.006745694,0.9556628,0.01923502],"study_design_scores_gemma":[0.0003862415,0.0002753739,0.003729744,0.001020748,0.00009278075,0.01481462,0.001802577,0.0007202627,0.0002820265,0.02162161,0.9551256,0.0001284017],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0008108378,0.001862624,0.00006489379,0.9816507,0.01266404,0.000005542595,0.0000130651,0.000009035074,0.002919276],"genre_scores_gemma":[0.01146952,0.002584451,0.0002609561,0.9348421,0.04409819,0.00002373938,0.00002496393,0.00002267676,0.006673458],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.04467987,"threshold_uncertainty_score":0.02872759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05570401843040445,"score_gpt":0.3671109963158031,"score_spread":0.3114069778853986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}