{"id":"W4372292091","doi":"10.3390/genes14051043","title":"TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins","year":2023,"lang":"en","type":"article","venue":"Genes","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario; Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada; University of Ottawa","keywords":"Transfer RNA; Biology; Mitochondrion; Translation (biology); Gene; Protein biosynthesis; Phenotype; Genetics; RNA; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008911327,0.00005449949,0.00008950933,0.00001763448,0.00002783646,0.000003403732,0.00007009356,0.00004785899,0.000005466281],"category_scores_gemma":[0.00003328141,0.00004188991,0.00002303352,0.0001312454,0.00009919903,0.000001402302,0.00002807246,0.00002905806,6.925953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003494726,"about_ca_system_score_gemma":0.00004784979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004773367,"about_ca_topic_score_gemma":0.00005810877,"domain_scores_codex":[0.9995954,0.0000156537,0.0001013124,0.0001348747,0.00006806883,0.00008468833],"domain_scores_gemma":[0.9996624,0.000005131514,0.00007925279,0.000151237,0.00008384471,0.00001814137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005928194,0.00008468324,0.1936313,0.00005845694,0.00004772804,0.000001210375,0.0001499425,0.00001816386,0.7985253,0.0001196084,0.0005115188,0.00679278],"study_design_scores_gemma":[0.0004143927,0.0003015189,0.4496417,0.00003604188,0.00001895706,0.000002986256,0.0001202955,0.0001009415,0.5473289,0.0001180763,0.001796722,0.0001194256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99822,0.0009057816,0.0003462865,0.0001150019,0.00001546976,0.00009204911,0.00008452414,0.000005590923,0.000215276],"genre_scores_gemma":[0.9990957,0.0003139779,0.0001028522,0.00001400393,0.00001298617,0.00001918548,0.00003699588,0.000005680221,0.0003985523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2560104,"threshold_uncertainty_score":0.1708221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590543062944171,"score_gpt":0.2560511831035138,"score_spread":0.2401457524740721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}