{"id":"W4372333907","doi":"10.1093/molbev/msad104","title":"Reduction of <i>Paraoxonase</i> Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization","year":2023,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Paraoxonase enzyme and polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"The Scarborough Hospital; University of Toronto","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Eye Institute; National Human Genome Research Institute; National Institute of General Medical Sciences; Museum of the North, University of Alaska; University of Washington","keywords":"Biology; Pseudogene; Paraoxonase; Gene; Adaptation (eye); Genetics; Evolutionary biology; Phylogenetics; Zoology; Genome; Enzyme; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009747306,0.0002028997,0.0001314061,0.0003305552,0.0002156696,0.0002358314,0.0002610347,0.0002407659,0.001002911],"category_scores_gemma":[0.0002181428,0.0001199571,0.0001764599,0.0001633095,0.000388559,0.0002578215,0.0002891934,0.0003831381,0.0002383823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001697897,"about_ca_system_score_gemma":0.0001227433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001273214,"about_ca_topic_score_gemma":0.00175432,"domain_scores_codex":[0.9998932,0.000008141233,0.00000631639,0.00005552223,0.00001839122,0.0000184962],"domain_scores_gemma":[0.9996881,0.00005129631,0.0001410212,0.00002888055,0.00004561801,0.00004504477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008739031,0.000008453797,0.02553726,0.00003411103,0.00001312762,0.0001224669,0.0001350842,0.00004665499,0.9713811,0.00008080163,0.00002066766,0.002532808],"study_design_scores_gemma":[0.000004240962,0.0002986838,0.802229,0.00000961331,0.00003038596,0.001235938,0.000427048,0.0006639751,0.1926561,0.0002460258,0.00218728,0.00001167956],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971354,0.0002358888,0.00166674,0.00003702015,0.000003514119,0.000007406995,0.0001957632,0.00003124552,0.0006869549],"genre_scores_gemma":[0.9975938,0.0001259448,0.001097274,0.00005893593,0.000002632486,0.00001005849,0.0004400366,0.00001339866,0.0006579075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001273214,"threshold_uncertainty_score":0.003355086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006908197102344555,"score_gpt":0.2806209512400284,"score_spread":0.2737127541376838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}