{"id":"W4372337303","doi":"10.1371/journal.ppat.1011367","title":"Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; Australian Research Council; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Children's Discovery Institute; W. M. Keck Foundation","keywords":"Klebsiella pneumoniae; Antigen; Microbiology; Bacterial capsule; Antibody; Biology; Lipopolysaccharide; Serotype; Conjugate vaccine; Immunization; Virology; Antibiotics; Escherichia coli; Streptococcus pneumoniae; Immunology; Virulence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002525727,0.0002434936,0.0003113301,0.00007722716,0.000150766,0.0000475942,0.0001210485,0.000246064,0.000007557402],"category_scores_gemma":[0.00009999575,0.0002344668,0.00007908172,0.0002052933,0.00007937168,0.00001170998,0.0002315147,0.0001229481,0.00001082038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001281885,"about_ca_system_score_gemma":0.00004941283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001096218,"about_ca_topic_score_gemma":0.00003415452,"domain_scores_codex":[0.9983751,0.00005987932,0.0003470752,0.0005865297,0.0001977437,0.0004337218],"domain_scores_gemma":[0.9992647,0.00002018436,0.0001536602,0.0003574688,0.00006663963,0.0001373571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005898285,0.00005383685,0.08628058,0.00007471701,0.00009742186,0.00002039284,0.0001430131,0.000002028135,0.9123819,0.00002555599,0.00004682574,0.0008147109],"study_design_scores_gemma":[0.0005407488,0.0002863679,0.3459454,0.00007221107,0.00006020458,0.00002379054,0.0004601712,0.0001914623,0.6518602,0.00002344603,0.0002627369,0.0002732232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987829,0.000245159,0.0001349518,0.0001065032,0.0001518766,0.0002470363,0.0002455128,0.00003920402,0.00004687191],"genre_scores_gemma":[0.9983016,0.0009992684,0.000153921,0.00004275855,0.0001614075,0.00000503263,0.0001587189,0.00004684418,0.0001304403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2605217,"threshold_uncertainty_score":0.956128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128970416079988,"score_gpt":0.2780185185604048,"score_spread":0.2567288143996049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}