{"id":"W4372337303","doi":"10.1371/journal.ppat.1011367","title":"Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; Australian Research Council; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Children's Discovery Institute; W. M. Keck Foundation","keywords":"Klebsiella pneumoniae; Antigen; Microbiology; Bacterial capsule; Antibody; Biology; Lipopolysaccharide; Serotype; Conjugate vaccine; Immunization; Virology; Antibiotics; Escherichia coli; Streptococcus pneumoniae; Immunology; Virulence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612462,0.000529506,0.0002383666,0.0001342344,0.00007237654,0.0001854744,0.0001999751,0.0002861687,0.0005917213],"category_scores_gemma":[0.0002023678,0.0001475479,0.0002268274,0.0001018995,0.0001467858,0.0001595663,0.000234849,0.0004599958,0.0001235538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990567,"about_ca_system_score_gemma":0.0002163645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006229482,"about_ca_topic_score_gemma":0.001028714,"domain_scores_codex":[0.9998061,0.00003338643,0.00001687314,0.00002649353,0.00004955391,0.0000674945],"domain_scores_gemma":[0.9998921,0.00001639094,0.00003899278,0.00001205593,0.00001713412,0.0000233348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001892885,0.0001078412,0.0001452383,0.00005357133,0.000008027423,0.00001840008,0.00001240679,0.0001532964,0.9974027,0.00003349001,0.0000289586,0.001846693],"study_design_scores_gemma":[0.00002601218,0.002559886,0.003764197,0.000008234623,0.00001975047,0.0001012636,0.00001369023,0.0007893852,0.9917961,0.00001510617,0.0009027102,0.000003748278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978598,0.0006785853,0.0008589692,0.00002963026,0.00001492777,0.00002411488,0.00005022158,0.00002159781,0.0004622292],"genre_scores_gemma":[0.997304,0.0005129297,0.0008661834,0.00004278181,0.00000639278,0.00002396133,0.0001540231,0.000008696808,0.001081047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006229482,"threshold_uncertainty_score":0.00197953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02128970416079988,"score_gpt":0.2780185185604048,"score_spread":0.2567288143996049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}