{"id":"W4372349325","doi":"10.1101/2023.05.04.23289196","title":"Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Inflammatory Biomarkers in Disease Prognosis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Krebshilfe; School of Public Health, Imperial College London; Knut och Alice Wallenbergs Stiftelse; World Cancer Research Fund; Versus Arthritis; Instituto de Salud Carlos III; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; National Institute for Health and Care Research; Agència de Gestió d'Ajuts Universitaris i de Recerca; Chonnam National University Hwasun Hospital; Institut National Du Cancer; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Imperial College London; Generalitat de Catalunya; University Hospitals Bristol NHS Foundation Trust; Canadian Institutes of Health Research; Cancerfonden; Grantová Agentura České Republiky; Institut Gustave-Roussy; Centres de Recerca de Catalunya; Umeå Universitet; Chonnam National University; NIHR Imperial Biomedical Research Centre; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; Ministerstvo Zdravotnictví Ceské Republiky; European Commission; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Bundesministerium für Bildung und Forschung; Division of Cancer Prevention, National Cancer Institute; University of Cambridge; Cancer Research UK; NIHR Bristol Biomedical Research Centre; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; Pelotonia; University of Bristol; Génome Québec; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; McGill University; Univerzita Karlova v Praze; Medical Research Council; Department of Health and Social Care; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Association (psychology); Medicine; Oncology; Mendelian inheritance; Cancer; Genetics; Internal medicine; Biology; Genotype; Gene; Psychology; Genetic variants","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002289106,0.0004627898,0.001133729,0.0009903992,0.0002145312,0.0001117948,0.0001820027,0.0008336856,0.0001213227],"category_scores_gemma":[0.002722398,0.0004684984,0.000589194,0.000939111,0.00007522041,0.00009025262,0.0003606069,0.0009952333,0.00002298271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007739733,"about_ca_system_score_gemma":0.0002689749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005191934,"about_ca_topic_score_gemma":0.0002090196,"domain_scores_codex":[0.9960321,0.0006258268,0.001006094,0.0009156228,0.0009353132,0.000485],"domain_scores_gemma":[0.9965777,0.0005451443,0.00135499,0.0006391922,0.0006181403,0.000264822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002679437,0.00001378326,0.9791856,0.0007826923,0.01575445,0.0000595618,0.000271471,0.0004912788,0.00006983862,0.000002276536,0.001622947,0.001478187],"study_design_scores_gemma":[0.002853128,0.00001244709,0.9565877,0.0004033261,0.02218592,9.596531e-7,0.00007633735,0.01698692,0.0001657802,0.0001921224,0.0001281841,0.0004071672],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913929,0.0003023449,0.0006802625,0.005026545,0.000334258,0.001352215,0.0002707067,0.0004529002,0.0001878739],"genre_scores_gemma":[0.9952819,0.0008971872,0.0007157809,0.0005130632,0.0007810099,0.0006515655,0.0007645242,0.0001160166,0.0002789281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02259786,"threshold_uncertainty_score":0.9997767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01864312975609113,"score_gpt":0.2856084372180587,"score_spread":0.2669653074619676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}