{"id":"W4372403945","doi":"10.1016/j.celrep.2023.112474","title":"Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute for Collaborative Biotechnologies; Army Research Office; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Gilead Sciences","keywords":"Metabolome; Biology; Bacterial vaginosis; Lactobacillus crispatus; PI3K/AKT/mTOR pathway; Microbiome; Transcriptome; Microbiology; Lactobacillus; Gardnerella vaginalis; Metabolomics; Signal transduction; Cell biology; Bioinformatics; Bacteria; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487895,0.0004103923,0.0004375477,0.0008258802,0.000369058,0.0007889076,0.0001620922,0.0003382713,0.001214984],"category_scores_gemma":[0.0003622579,0.0002056712,0.00039071,0.0005966275,0.0002787287,0.0003268814,0.0005499418,0.0003114642,0.0002123671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003181093,"about_ca_system_score_gemma":0.0003310049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089485,"about_ca_topic_score_gemma":0.00111871,"domain_scores_codex":[0.999745,0.00006138877,0.00001797284,0.00005649781,0.00006284839,0.00005633393],"domain_scores_gemma":[0.9998655,0.00001766531,0.00007007137,0.000007878444,0.00001921817,0.00001963242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00128901,0.0001005978,0.09357005,0.00067377,0.0002167263,0.0008711037,0.0002442499,0.0002875007,0.8633646,0.0003050626,0.0004842036,0.03859308],"study_design_scores_gemma":[0.00002469511,0.0006617196,0.8091713,0.0001854608,0.0002225553,0.002680437,0.001203651,0.001520169,0.1772615,0.0006207033,0.006416931,0.00003089045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980678,0.01448705,0.001358258,0.000407949,0.00003181931,0.00003515234,0.00141712,0.00005360598,0.001531098],"genre_scores_gemma":[0.9911988,0.005622711,0.001624613,0.0001378787,0.00002178668,0.00003141843,0.000629815,0.00001062571,0.0007224663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001214984,"threshold_uncertainty_score":0.0040645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440108020024469,"score_gpt":0.2558933333310859,"score_spread":0.2414922531308412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}