{"id":"W4372403945","doi":"10.1016/j.celrep.2023.112474","title":"Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Institute for Collaborative Biotechnologies; Army Research Office; Bill and Melinda Gates Foundation; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Gilead Sciences","keywords":"Metabolome; Biology; Bacterial vaginosis; Lactobacillus crispatus; PI3K/AKT/mTOR pathway; Microbiome; Transcriptome; Microbiology; Lactobacillus; Gardnerella vaginalis; Metabolomics; Signal transduction; Cell biology; Bioinformatics; Bacteria; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001132179,0.0001596965,0.000198931,0.0001981681,0.0004046058,0.00003924594,0.0001158896,0.0001697898,0.0007895208],"category_scores_gemma":[0.0003674371,0.0001131929,0.00006699307,0.0005845395,0.0003293359,0.0001039761,0.0001413864,0.0003877739,0.001010704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003361878,"about_ca_system_score_gemma":0.00007266914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547403,"about_ca_topic_score_gemma":0.000002223616,"domain_scores_codex":[0.9984863,0.0002025961,0.0003376692,0.0005197634,0.00007090042,0.0003827343],"domain_scores_gemma":[0.9988903,0.0002504414,0.0001638802,0.0005219726,0.0001435695,0.00002980728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002767831,0.00005520534,0.002856467,0.00001297715,0.00009551283,0.00003810214,0.0001846417,0.000002513674,0.9173817,0.000003139053,0.07784561,0.001496446],"study_design_scores_gemma":[0.0002386582,0.00005813556,0.004259114,0.000004198888,0.0000355955,0.0005126109,0.0001171356,0.000002069768,0.686524,0.00009095859,0.3080513,0.000106181],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924695,0.003049942,0.00006904019,0.0009083962,0.001424076,0.0003524131,0.00004165538,0.0001704481,0.00151446],"genre_scores_gemma":[0.9719341,0.0002720846,0.0000144295,0.00008836787,0.00007786683,0.00005529979,0.0002519254,0.00002502108,0.02728089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2308577,"threshold_uncertainty_score":0.9997671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440108020024469,"score_gpt":0.2558933333310859,"score_spread":0.2414922531308412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}