{"id":"W4375812385","doi":"10.2139/ssrn.4436849","title":"Disease Tolerance of Malaria Involves Epigenetic Reprogramming of Innate Immune Cells","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Epigenetics; Biology; Immunology; Parasitemia; Reprogramming; Malaria; Innate immune system; Immunity; Immune system; Acquired immune system; Inflammation; Histone; DNA methylation; Disease; Plasmodium falciparum; Genetics; Cell; Medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810756,0.00010937,0.0001827006,0.0001039857,0.00009912068,0.0003992323,0.0001026177,0.0002009187,0.004756225],"category_scores_gemma":[0.0002738023,0.00007435579,0.0001418926,0.00009319888,0.0001879015,0.0002284104,0.0002555012,0.000534607,0.0006290441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001658413,"about_ca_system_score_gemma":0.000113253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005630409,"about_ca_topic_score_gemma":0.00009055751,"domain_scores_codex":[0.9998702,0.00002564719,0.000006134731,0.00002955881,0.00003272842,0.00003574249],"domain_scores_gemma":[0.9999198,0.0000128833,0.00002500049,0.00001926384,0.0000101158,0.00001296405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005047389,0.00006082015,0.002234253,0.0001585757,0.00002733562,0.0002903144,0.0001083666,0.0003309626,0.9182317,0.009901379,0.001876713,0.06627478],"study_design_scores_gemma":[0.0001028942,0.001338825,0.07465228,0.00009999761,0.00008534191,0.003261853,0.0003210763,0.003417226,0.8378175,0.01870059,0.06017256,0.00003001539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465163,0.01067997,0.01343405,0.002522749,0.0007136232,0.00004116938,0.0006689547,0.0003030608,0.02512007],"genre_scores_gemma":[0.9906229,0.001619485,0.001349302,0.0002469753,0.0001396096,0.00001420948,0.0002044752,0.00002928465,0.005773671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004756225,"threshold_uncertainty_score":0.0159111,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01646421956596373,"score_gpt":0.26647616544784,"score_spread":0.2500119458818763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}