{"id":"W4375855965","doi":"10.1186/s13195-023-01232-7","title":"Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer’s disease","year":2023,"lang":"en","type":"review","venue":"Alzheimer s Research & Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität zu Lübeck; NIHR Oxford Biomedical Research Centre; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; Parkinson's UK; National Institute for Health and Care Research; Alzheimer Society; Cure Alzheimer's Fund; National Science Foundation","keywords":"dNaM; Epigenome; Epigenetics; DNA methylation; Entorhinal cortex; CpG site; Biology; Methylation; Genetics; Genetic association; Bioinformatics; Single-nucleotide polymorphism; Neuroscience; Gene; Hippocampus; Gene expression; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003408809,0.0006807867,0.001176873,0.0007747042,0.0003455217,0.0002479087,0.0008053088,0.0006539749,0.00006977341],"category_scores_gemma":[0.0005531203,0.0006096779,0.0005730753,0.0009984558,0.00007847279,0.00002290842,0.0003661059,0.0008811125,0.0001158875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002338531,"about_ca_system_score_gemma":0.0007271097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003227722,"about_ca_topic_score_gemma":0.0003144569,"domain_scores_codex":[0.9927438,0.002084897,0.001138765,0.00137155,0.001582737,0.001078232],"domain_scores_gemma":[0.9969376,0.0007415081,0.0005017521,0.0009897575,0.0004664833,0.0003628896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006740011,0.003235933,0.01372472,0.0006828743,0.01599727,0.000129697,0.0008916651,0.00006182221,0.005902566,0.0001170817,0.001280844,0.9573015],"study_design_scores_gemma":[0.001914669,0.0009054976,0.01849503,0.0005723481,0.001499401,3.261278e-7,0.00007889399,0.00004276183,0.0005769954,0.0002439428,0.9745566,0.001113509],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01165018,0.9835021,0.0002395434,0.000137642,0.0004764836,0.003781877,0.00009994092,0.00004243201,0.00006979388],"genre_scores_gemma":[0.03291626,0.9629313,0.00004961219,0.00002072379,0.0009908658,0.0008122666,0.001680145,0.0002131325,0.0003856299],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9732758,"threshold_uncertainty_score":0.9996355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.244670064074982,"score_gpt":0.4311838912147881,"score_spread":0.1865138271398061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}