{"id":"W4375856092","doi":"10.1016/j.jconrel.2023.05.004","title":"Fluid flow influences ultrasound-assisted endothelial membrane permeabilization and calcium flux","year":2023,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Canadian Aeronautics and Space Institute; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Heart and Stroke Foundation of Canada; Burroughs Wellcome Fund","keywords":"Microbubbles; Ultrasound; Propidium iodide; Permeability (electromagnetism); Biophysics; Sonoporation; Endothelial stem cell; Intracellular; Chemistry; Membrane permeability; Membrane; Biomedical engineering; Medicine; Biology; Apoptosis; Biochemistry; In vitro; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003999729,0.0002425657,0.0002569351,0.0001773477,0.0002640772,0.0008735711,0.000352335,0.0006395911,0.002814039],"category_scores_gemma":[0.001021298,0.0002304746,0.0002281101,0.0001444281,0.0006014723,0.0009283632,0.0002374267,0.0006656947,0.0003039901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005316574,"about_ca_system_score_gemma":0.0003619292,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296798,"about_ca_topic_score_gemma":0.0007595178,"domain_scores_codex":[0.999721,0.00007584426,0.00001818128,0.00004387085,0.00003488831,0.0001061827],"domain_scores_gemma":[0.999494,0.0003180076,0.00007382777,0.00002073111,0.00004310806,0.00005032778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001165511,0.00006238748,0.0001194974,0.00004833388,0.00000691707,0.00004927815,0.0000594315,0.00009704356,0.9966878,0.0002388641,0.00005813444,0.001406799],"study_design_scores_gemma":[0.00008277677,0.0001909229,0.001173126,0.000005055217,0.00001569181,0.00004431939,0.00003011947,0.001537525,0.9962844,0.00005114018,0.0005765435,0.00000830184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960145,0.0008259788,0.001616108,0.0001693741,0.00004832025,0.00002246447,0.00009524776,0.00003256284,0.001175561],"genre_scores_gemma":[0.9976534,0.0003667297,0.0008327477,0.00007230109,0.0000196287,0.000015959,0.00005975245,0.00001726486,0.0009622395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002814039,"threshold_uncertainty_score":0.009413838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01172223414767302,"score_gpt":0.2340884514656708,"score_spread":0.2223662173179978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}