{"id":"W4375856101","doi":"10.1016/j.ijcard.2023.04.058","title":"Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV","year":2023,"lang":"en","type":"article","venue":"International Journal of Cardiology","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; Manitoba Health","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; Ministerio de Economía y Competitividad; National Institutes of Health; National Heart, Lung, and Blood Institute","keywords":"Medicine; Myocardial infarction; Population; Internal medicine; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008363505,0.0006223029,0.0003615608,0.001191024,0.000823638,0.001143025,0.0004630743,0.0008234112,0.00381507],"category_scores_gemma":[0.004802297,0.0003357302,0.0007642905,0.001579265,0.0005232557,0.0006107861,0.0006842855,0.001368601,0.0002187291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001957096,"about_ca_system_score_gemma":0.0002876066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005178371,"about_ca_topic_score_gemma":0.00552996,"domain_scores_codex":[0.9992642,0.000348974,0.00006051994,0.0001220758,0.00009911908,0.0001051603],"domain_scores_gemma":[0.997848,0.0007966774,0.0007487471,0.0002195756,0.0001583938,0.0002286112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001439613,0.00005281959,0.9958987,0.000008673645,0.0002215912,0.0001856618,0.0001104872,0.0001257232,0.0004586851,0.000235683,0.00007670502,0.002481208],"study_design_scores_gemma":[0.000004553902,0.00006533987,0.9978605,0.000009130794,0.0001321056,0.0003257871,0.0001561545,0.0007157911,0.00007635982,0.0005553508,0.00009263388,0.000006249189],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969091,0.0005055788,0.0005618621,0.0003005184,0.00002171194,0.000009980537,0.0002311708,0.000007815851,0.001452274],"genre_scores_gemma":[0.9992766,0.0001122253,0.0002098881,0.00004288315,0.00003066179,0.000003066938,0.000103586,0.000002636554,0.000218479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005178371,"threshold_uncertainty_score":0.01276273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01187592416648285,"score_gpt":0.2900524267571803,"score_spread":0.2781765025906975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}