{"id":"W4375859145","doi":"10.1038/s41588-023-01384-0","title":"Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; Mount Sinai Hospital; University of Manitoba","funders":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University; Japan Society for the Promotion of Science; University of Science and Technology of China; National Human Genome Research Institute; Genome Institute of Singapore; National Research Foundation of Korea; National Natural Science Foundation of China; National University of Singapore; National Research Foundation; Massachusetts General Hospital; Helsinki Institute of Life Science, Helsingin Yliopisto; National Center for Global Health and Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; Stanley Center for Psychiatric Research, Broad Institute; Kela; Guangzhou Medical University; Broad Institute; Cedars-Sinai Medical Center; Japan Agency for Medical Research and Development; Tongji University; University of Ulsan; Helsingin Yliopisto","keywords":"Biology; Inflammatory bowel disease; Genetic architecture; Inflammatory Bowel Diseases; Genetics; Computational biology; Evolutionary biology; Disease; Gene; Phenotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001226358,0.0002195621,0.0001200169,0.00003668086,0.0001693464,0.00003600377,0.0004321952,0.0002215461,0.000003582696],"category_scores_gemma":[0.000144789,0.0001718451,0.0001163473,0.0001688999,0.0004126489,0.0000026782,0.0004842661,0.0002627566,0.000008795427],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005202856,"about_ca_system_score_gemma":0.0001014032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.425292e-7,"about_ca_topic_score_gemma":0.00003406569,"domain_scores_codex":[0.9986725,0.0001512032,0.0002335674,0.0003625198,0.000246668,0.0003334771],"domain_scores_gemma":[0.9989684,0.000007642177,0.0001264882,0.0006638977,0.00009447862,0.0001391597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001300818,0.00003213681,0.9572399,0.0002114081,0.00008288957,0.00009465925,0.0005778777,0.001186697,0.03092193,0.00002525915,0.002929892,0.006567323],"study_design_scores_gemma":[0.0003702278,0.00003792758,0.9822403,0.00002837269,0.00003417127,0.00001430724,0.0001851785,0.00003111578,0.005495177,0.0001383467,0.0112245,0.0002004022],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954787,0.003104074,0.00001961163,0.0002055544,0.0003145786,0.0002506137,0.0002510097,0.00003660685,0.0003391975],"genre_scores_gemma":[0.9985299,0.0002700085,0.0001737511,0.0002475868,0.0004286602,0.000009935255,0.00004892786,0.000049877,0.0002413586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02542675,"threshold_uncertainty_score":0.700764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004628428638804087,"score_gpt":0.2317955717186687,"score_spread":0.2271671430798646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}