{"id":"W4375859145","doi":"10.1038/s41588-023-01384-0","title":"Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries","year":2023,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":218,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Heart Institute; Mount Sinai Hospital; University of Manitoba","funders":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University; Japan Society for the Promotion of Science; University of Science and Technology of China; National Human Genome Research Institute; Genome Institute of Singapore; National Research Foundation of Korea; National Natural Science Foundation of China; National University of Singapore; National Research Foundation; Massachusetts General Hospital; Helsinki Institute of Life Science, Helsingin Yliopisto; National Center for Global Health and Medicine; National Institute of Diabetes and Digestive and Kidney Diseases; Stanley Center for Psychiatric Research, Broad Institute; Kela; Guangzhou Medical University; Broad Institute; Cedars-Sinai Medical Center; Japan Agency for Medical Research and Development; Tongji University; University of Ulsan; Helsingin Yliopisto","keywords":"Biology; Inflammatory bowel disease; Genetic architecture; Inflammatory Bowel Diseases; Genetics; Computational biology; Evolutionary biology; Disease; Gene; Phenotype; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006340176,0.0005099881,0.0005032396,0.002064881,0.000642586,0.0008582915,0.0004447086,0.0004902852,0.003427406],"category_scores_gemma":[0.001307657,0.0003338941,0.0006151194,0.002230817,0.0007326695,0.0003845195,0.000987449,0.0004912414,0.0002816699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003176977,"about_ca_system_score_gemma":0.0002967075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005766891,"about_ca_topic_score_gemma":0.004636155,"domain_scores_codex":[0.9988997,0.0003954397,0.0001088564,0.0003104433,0.0001196822,0.0001658722],"domain_scores_gemma":[0.9991461,0.0002264574,0.0002835843,0.00008938759,0.0001117235,0.0001427052],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001931799,0.000127159,0.9220882,0.00008250037,0.00105132,0.002542543,0.001829579,0.0004946049,0.05251276,0.002217847,0.0003265644,0.01479514],"study_design_scores_gemma":[0.00001368097,0.00007577144,0.9964978,0.00001942658,0.0001710491,0.001189648,0.0004699606,0.0001818857,0.0004757224,0.0005109758,0.0003836149,0.00001046719],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974291,0.0007099057,0.0003202743,0.0001268009,0.000007362533,0.000004403289,0.0001809821,0.000007102892,0.001213976],"genre_scores_gemma":[0.9986444,0.0004418306,0.0002453407,0.00004565499,0.00001188053,0.000004742411,0.0001513291,0.000009968481,0.0004448564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005766891,"threshold_uncertainty_score":0.01146668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004628428638804087,"score_gpt":0.2317955717186687,"score_spread":0.2271671430798646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}