{"id":"W4375859703","doi":"10.1128/aac.01709-22","title":"Amplicon Deep Sequencing Reveals Multiple Genetic Events Lead to Treatment Failure with Atovaquone-Proguanil in Plasmodium falciparum","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Calgary","funders":"National Institute of Allergy and Infectious Diseases; Grand Challenges Canada; National Institutes of Health; University of Calgary","keywords":"Atovaquone; Haplotype; Plasmodium falciparum; Biology; Malaria; Proguanil; Amplicon; Deep sequencing; Virology; Genetics; Genotyping; Genotype; Immunology; Polymerase chain reaction; Gene; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001902413,0.0001555502,0.0001559468,0.0001805036,0.00018696,0.0002293018,0.0001351467,0.0002582006,0.0006656998],"category_scores_gemma":[0.000406664,0.0001216632,0.0001523164,0.0001705316,0.0001428908,0.00008468772,0.0001650379,0.0002829347,0.0001254876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002262833,"about_ca_system_score_gemma":0.0001416997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002238751,"about_ca_topic_score_gemma":0.004251847,"domain_scores_codex":[0.9998685,0.00002460797,0.0000080441,0.00003533808,0.00003074234,0.0000328123],"domain_scores_gemma":[0.9997942,0.00006015833,0.00005421559,0.00001404593,0.00003922096,0.00003813801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008864948,0.0001280318,0.1330729,0.00009889511,0.00008066528,0.001917308,0.0005944366,0.001632206,0.8410653,0.0001923538,0.0008298557,0.01950138],"study_design_scores_gemma":[0.00003795117,0.0009220349,0.8391867,0.00003490169,0.0001322991,0.004005631,0.0007305174,0.01663017,0.1331822,0.0003133334,0.004792319,0.00003192674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980703,0.000103775,0.001096948,0.00003998397,0.000003625575,0.000009171948,0.000479743,0.00001511011,0.0001814767],"genre_scores_gemma":[0.9975159,0.0000451328,0.001438265,0.00005149031,0.000001403747,0.000009775556,0.0006485146,0.000006815638,0.0002826832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002238751,"threshold_uncertainty_score":0.004451454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02639723525889516,"score_gpt":0.2821427364853617,"score_spread":0.2557455012264666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}