{"id":"W4375859979","doi":"10.1128/spectrum.00994-23","title":"The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Response Biomedical (Canada); Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Public Health Agency; Public Health Agency of Canada","keywords":"Protein kinase R; Biology; Virology; RNase P; Coronavirus; RNA silencing; RNA; Viral protein; Antiviral protein; Vero cell; Phosphorylation; Virus; Cell biology; Protein kinase A; RNA interference; Gene; Genetics; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001244926,0.0002478595,0.0001556693,0.00008352782,0.000149429,0.0002309075,0.0001008607,0.0002655157,0.0009207982],"category_scores_gemma":[0.0001080153,0.00008274755,0.0002815805,0.0000521349,0.0002261869,0.0001638798,0.0001897165,0.0004142243,0.0003128558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002473411,"about_ca_system_score_gemma":0.0001916101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227333,"about_ca_topic_score_gemma":0.0006807448,"domain_scores_codex":[0.9999027,0.00002224884,0.000006337358,0.00001935215,0.00002951042,0.00001976644],"domain_scores_gemma":[0.9999349,0.00001019067,0.00002137153,0.000008008014,0.000008566392,0.00001696092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004520683,0.00001479553,0.0003592474,0.00001664534,0.000004930354,0.00004820979,0.000008863218,0.00005274594,0.998494,0.000134767,0.00001889994,0.0008017364],"study_design_scores_gemma":[0.00002117229,0.0007585797,0.01725349,0.00001073985,0.0000199656,0.001909379,0.00008030998,0.001042059,0.9722868,0.0002207586,0.00638935,0.000007380795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895269,0.003067322,0.002595306,0.0002353491,0.00004106497,0.00002473692,0.0001401023,0.0000323145,0.004336904],"genre_scores_gemma":[0.9945417,0.0005425232,0.002939753,0.00009554566,0.00001188746,0.00001173642,0.0003724704,0.000006151487,0.00147826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009207982,"threshold_uncertainty_score":0.003080368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999598301644783,"score_gpt":0.2519106809018806,"score_spread":0.2319146978854328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}