{"id":"W4375859979","doi":"10.1128/spectrum.00994-23","title":"The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways","year":2023,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Response Biomedical (Canada); Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Public Health Agency; Public Health Agency of Canada","keywords":"Protein kinase R; Biology; Virology; RNase P; Coronavirus; RNA silencing; RNA; Viral protein; Antiviral protein; Vero cell; Phosphorylation; Virus; Cell biology; Protein kinase A; RNA interference; Gene; Genetics; Coronavirus disease 2019 (COVID-19); Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002000678,0.0001481358,0.00020669,0.00005343651,0.0001302216,0.000009909527,0.00008804485,0.0001601774,0.000003187176],"category_scores_gemma":[0.0001525356,0.0001162255,0.00005415229,0.0001328232,0.0003523414,0.000007986444,0.0001577651,0.00008824175,0.00000852937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007422559,"about_ca_system_score_gemma":0.00005246827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002101462,"about_ca_topic_score_gemma":0.0001280801,"domain_scores_codex":[0.9990377,0.0001219563,0.0002631542,0.0002914008,0.00003653905,0.0002492873],"domain_scores_gemma":[0.9994644,0.00004727425,0.000228315,0.000169267,0.00005411802,0.00003664117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001696009,0.00002952925,0.007100857,0.00002962954,0.00004619098,0.000007981768,0.00008713706,0.000001495685,0.9914198,0.0005741176,0.0003856904,0.0001479497],"study_design_scores_gemma":[0.000873217,0.0002139738,0.01424019,0.0000287312,0.00001674897,0.00001729522,0.0001880817,0.00009455895,0.9825891,0.0003068242,0.001299648,0.0001316429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971857,0.001543025,0.000008522346,0.0003764996,0.00005394964,0.0003145933,0.0002808597,0.00001751475,0.0002193452],"genre_scores_gemma":[0.9991248,0.0003501174,0.00002750118,0.00009356609,0.00003306208,0.00001050343,0.0001795566,0.00001617645,0.0001647277],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008830735,"threshold_uncertainty_score":0.4739537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999598301644783,"score_gpt":0.2519106809018806,"score_spread":0.2319146978854328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}