{"id":"W4375860631","doi":"10.1164/rccm.202301-0021oc","title":"Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged ≥6 Years with Cystic Fibrosis and at Least One <i>F508del</i> Allele: A Phase 3, Open-Label Clinical Trial","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute for Health and Care Research; Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Clinical trial; Pediatrics; Intensive care medicine; Internal medicine; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001765115,0.0002905096,0.001671744,0.0003882488,0.0001097119,0.00003282155,0.0002464578,0.0001022376,0.00005767138],"category_scores_gemma":[0.004285627,0.0002156482,0.00006826549,0.0006895066,0.003712165,0.000208524,0.0002777127,0.000770231,0.000001588898],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009215577,"about_ca_system_score_gemma":0.0002893366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003875355,"about_ca_topic_score_gemma":0.00000650938,"domain_scores_codex":[0.9961762,0.0005672977,0.001350904,0.0005021497,0.0009108456,0.0004926274],"domain_scores_gemma":[0.995679,0.00233478,0.0003794208,0.0003116482,0.0003352287,0.0009599715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3011192,0.001333153,0.4500806,0.000557938,0.0003593757,0.001204912,0.0002593586,0.000001387814,0.008359421,0.00004858443,0.0004576764,0.2362183],"study_design_scores_gemma":[0.1506922,0.07238074,0.7724093,0.001687551,0.0004890026,0.0004850544,0.0009313053,0.000007418397,0.0001122644,0.00001001584,0.000567375,0.0002277846],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922166,0.006319979,0.00007753013,0.0004702289,0.00002493557,0.0007934286,0.00005302791,0.00001622054,0.00002801764],"genre_scores_gemma":[0.9968343,0.001147854,0.0009264665,0.0005055551,0.0004917574,0.00001187469,0.00002234182,0.00004123599,0.00001865843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3223287,"threshold_uncertainty_score":0.9989992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05270663079786454,"score_gpt":0.4183995413697495,"score_spread":0.365692910571885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}