{"id":"W4375860631","doi":"10.1164/rccm.202301-0021oc","title":"Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged ≥6 Years with Cystic Fibrosis and at Least One <i>F508del</i> Allele: A Phase 3, Open-Label Clinical Trial","year":2023,"lang":"en","type":"article","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute for Health and Care Research; Vertex Pharmaceuticals","keywords":"Ivacaftor; Medicine; Cystic fibrosis; Clinical trial; Pediatrics; Intensive care medicine; Internal medicine; Cystic fibrosis transmembrane conductance regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002408317,0.0007767269,0.001484715,0.0002519046,0.0004499215,0.0008342536,0.0005929314,0.001179056,0.00201067],"category_scores_gemma":[0.001551041,0.0003025751,0.001483362,0.0002424045,0.0007099623,0.0008419208,0.0002959385,0.00292292,0.0005232632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005751835,"about_ca_system_score_gemma":0.001183287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000891419,"about_ca_topic_score_gemma":0.002200714,"domain_scores_codex":[0.9991226,0.0004626301,0.00006042371,0.0001094199,0.0001133582,0.0001315979],"domain_scores_gemma":[0.998268,0.0003547324,0.0004814446,0.00008865426,0.0001299798,0.0006770903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7877297,0.0465911,0.02432068,0.0009834059,0.001934614,0.0006474442,0.0003483254,0.001042724,0.0378621,0.0002125013,0.003028338,0.09529911],"study_design_scores_gemma":[0.4058245,0.5323099,0.05180734,0.0001374057,0.0008049518,0.000719959,0.00011674,0.000615518,0.004857778,0.0001166422,0.002647402,0.00004182549],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945548,0.002995796,0.0002216489,0.0002337878,0.0000560898,0.0006288557,0.0006455346,0.00002608771,0.0006374501],"genre_scores_gemma":[0.9942926,0.001710874,0.0007523684,0.0005587468,0.000122416,0.0008461663,0.0009530504,0.00001159763,0.0007521847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002408317,"threshold_uncertainty_score":0.0127365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05270663079786454,"score_gpt":0.4183995413697495,"score_spread":0.365692910571885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}