{"id":"W4375860850","doi":"10.1186/s40478-023-01558-1","title":"ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics","year":2023,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"European Social Fund; NIHR Newcastle Biomedical Research Centre; Instituto de Salud Carlos III; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institute on Aging; Instituto Carlos Slim de la Salud; Alzheimer's Society; Newcastle upon Tyne Hospitals NHS Foundation Trust; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Economic and Social Research Council; European Commission; Gun och Bertil Stohnes Stiftelse; Engineering and Physical Sciences Research Council; Medical Research Foundation; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research","keywords":"CADASIL; Pathology; Microglia; Leukoencephalopathy; Vascular smooth muscle; Medicine; Cerebral amyloid angiopathy; Biology; Inflammation; Immunology; Internal medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005313836,0.0004922734,0.0006597363,0.0004754877,0.0001943966,0.0004896491,0.000324152,0.0007758636,0.001432437],"category_scores_gemma":[0.0002707697,0.0000777231,0.0003540936,0.0002168085,0.0003412402,0.0002789472,0.0002735766,0.000798623,0.0002527652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000464483,"about_ca_system_score_gemma":0.000292685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002692198,"about_ca_topic_score_gemma":0.0003995152,"domain_scores_codex":[0.9999005,0.00003480248,0.00001187988,0.00001242252,0.00001672117,0.00002364285],"domain_scores_gemma":[0.9998534,0.00003348667,0.00003415488,0.00001217173,0.00003468904,0.0000320962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01227932,0.004288747,0.01295513,0.007392034,0.0006547724,0.01834356,0.0002930187,0.001647786,0.2499315,0.008995123,0.02145093,0.6617681],"study_design_scores_gemma":[0.01230645,0.06836744,0.139649,0.009027855,0.00316986,0.07406764,0.001549031,0.01372077,0.2167251,0.04714661,0.4139355,0.000334835],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2295581,0.7415871,0.004312038,0.01108445,0.001306176,0.000271446,0.0002749403,0.0002181608,0.0113875],"genre_scores_gemma":[0.8098944,0.1771391,0.00370316,0.003628452,0.001664846,0.0002283825,0.0003089643,0.00001318289,0.00341948],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001432437,"threshold_uncertainty_score":0.004792035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.156869232504868,"score_gpt":0.3797331042039471,"score_spread":0.222863871699079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}