{"id":"W4375862671","doi":"10.1161/circresaha.122.322213","title":"Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis","year":2023,"lang":"en","type":"article","venue":"Circulation Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; American Heart Association","keywords":"FKBP5; Gene knockdown; Transcription factor; Downregulation and upregulation; Medicine; Heat shock protein; Internal medicine; Endocrinology; Chemistry; Cardiology; Receptor; Glucocorticoid receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123281,0.0002314204,0.0001873959,0.0001426529,0.000173006,0.0002232069,0.00009931312,0.0002690584,0.001541108],"category_scores_gemma":[0.0001084305,0.00009163186,0.0001963874,0.00006992416,0.0001754469,0.0001079077,0.0001788701,0.0004120072,0.0004249187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784854,"about_ca_system_score_gemma":0.0000922183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003772583,"about_ca_topic_score_gemma":0.000644094,"domain_scores_codex":[0.9999044,0.00001095284,0.00001303536,0.00002434503,0.00002021348,0.00002701718],"domain_scores_gemma":[0.9998568,0.00002179619,0.0000529471,0.00001140999,0.00001311952,0.00004390511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001290228,0.00001915324,0.0006911421,0.00004283043,0.000008675877,0.00009410667,0.00001081062,0.00002894638,0.9980091,0.00004600617,0.00006784133,0.0008523928],"study_design_scores_gemma":[0.00007607495,0.001068061,0.1164284,0.00004331248,0.0001555699,0.002073027,0.000100926,0.002295419,0.8704621,0.0001441126,0.007138597,0.00001440837],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952598,0.002120926,0.001503843,0.0001061189,0.00003020914,0.000009270397,0.0002376844,0.00005509366,0.0006770418],"genre_scores_gemma":[0.9981493,0.0004711875,0.000338404,0.00003680638,0.000007111479,0.00001187152,0.0002360251,0.000004985784,0.0007443174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001541108,"threshold_uncertainty_score":0.005155504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027137608035742,"score_gpt":0.392591930469764,"score_spread":0.2898781696661897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}