{"id":"W4375862671","doi":"10.1161/circresaha.122.322213","title":"Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis","year":2023,"lang":"en","type":"article","venue":"Circulation Research","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; American Heart Association","keywords":"FKBP5; Gene knockdown; Transcription factor; Downregulation and upregulation; Medicine; Heat shock protein; Internal medicine; Endocrinology; Chemistry; Cardiology; Receptor; Glucocorticoid receptor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001080758,0.00006884449,0.0000837574,0.0001613785,0.0001022045,0.00001923226,0.0001354212,0.0001165429,0.00005651133],"category_scores_gemma":[0.0008310884,0.00007282595,0.0001042313,0.0006239418,0.0001091866,0.000004118599,0.00009681183,0.00006115755,0.00007299029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001690689,"about_ca_system_score_gemma":0.000135782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001631116,"about_ca_topic_score_gemma":0.000003665315,"domain_scores_codex":[0.9986441,0.0002034829,0.0001975591,0.0002707515,0.0004547349,0.0002293834],"domain_scores_gemma":[0.9990842,0.00006537055,0.00005187478,0.0003638387,0.0003662453,0.00006846847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007971349,0.00001826147,0.02051015,0.00004237075,0.000031241,0.000002580565,0.00005697775,0.011219,0.963614,0.0001526361,0.001450771,0.002822313],"study_design_scores_gemma":[0.0008955939,0.0001477169,0.3435522,0.00003394577,0.00001723727,0.000004368056,0.0000830538,0.00798546,0.6433892,0.001652184,0.002033804,0.0002052617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984949,0.0001840672,0.0003608193,0.0001609662,0.0001074908,0.0003064141,0.00002536719,0.00003127666,0.0003287166],"genre_scores_gemma":[0.9985737,0.00001638162,0.00008659949,0.000005259235,0.0006312912,0.00002395964,0.000379207,0.00001899977,0.0002646038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.323042,"threshold_uncertainty_score":0.2969756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027137608035742,"score_gpt":0.392591930469764,"score_spread":0.2898781696661897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}