{"id":"W4375950272","doi":"10.1111/liv.15592","title":"Optimizing therapy in primary biliary cholangitis: Alkaline phosphatase at six months identifies one‐year non‐responders and predicts survival","year":2023,"lang":"en","type":"article","venue":"Liver International","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta Hospital; University of Alberta; Toronto General Hospital; University Health Network","funders":"Norgine; Moderna; Dr. Falk Pharma; GlaxoSmithKline; Bristol-Myers Squibb; Ipsen; Canadian Liver Foundation; CymaBay Therapeutics; Regeneron Pharmaceuticals; Canadian Institutes of Health Research; Intercept Pharmaceuticals; Gilead Sciences; Falk Foundation","keywords":"Ursodeoxycholic acid; Medicine; Alkaline phosphatase; Internal medicine; Bilirubin; Gastroenterology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009195248,0.0002243862,0.0005916094,0.0007083137,0.0002166364,0.0005113732,0.0001988256,0.0003498299,0.0008733892],"category_scores_gemma":[0.001852477,0.00008677376,0.0004969266,0.0007078531,0.0002031942,0.0003022631,0.0003127163,0.0003503087,0.0002959179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002359785,"about_ca_system_score_gemma":0.0002237572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007235966,"about_ca_topic_score_gemma":0.001088891,"domain_scores_codex":[0.999587,0.0001338207,0.00006838181,0.00005270849,0.00009426461,0.00006380807],"domain_scores_gemma":[0.9983524,0.0003828284,0.0008134497,0.00005568836,0.0001526382,0.0002429963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003475722,0.00002839487,0.9968189,0.0000141751,0.00002372661,0.00003652662,0.00002376989,0.0000627696,0.0001815933,0.000003336796,0.00005673438,0.00240254],"study_design_scores_gemma":[0.00001175064,0.0003468058,0.9982957,0.00001082154,0.00004156228,0.0004084107,0.00008177057,0.000363002,0.0002451007,0.00002033296,0.0001714639,0.000003146825],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989926,0.0005086637,0.00006613057,0.00005402858,0.00000414162,0.000006483761,0.0001299612,0.000004301941,0.0002335158],"genre_scores_gemma":[0.9995064,0.000108619,0.00005089223,0.00001677489,0.000006888343,0.000005397423,0.0002323629,8.873063e-7,0.00007180207],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009195248,"threshold_uncertainty_score":0.004862964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682759108730525,"score_gpt":0.270763134791674,"score_spread":0.2439355437043687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}