{"id":"W4375955468","doi":"10.1371/journal.pbio.3002110","title":"MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii","year":2023,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Larner College of Medicine, University of Vermont; National Institutes of Health; National Institute of General Medical Sciences; American Heart Association; Cytokinetics; Wellcome Trust","keywords":"Biology; Toxoplasma gondii; Motility; Parasite hosting; Virulence; Virology; Myosin; Microbiology; Cell biology; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144454,0.000438032,0.0004786685,0.0003215831,0.0002649846,0.0003820577,0.0002478749,0.0003761777,0.001267309],"category_scores_gemma":[0.0001265061,0.0001974946,0.0002496928,0.0002770049,0.0001728128,0.0001408988,0.000216631,0.0005978494,0.0004337814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003888627,"about_ca_system_score_gemma":0.000357026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372606,"about_ca_topic_score_gemma":0.004976075,"domain_scores_codex":[0.9999105,0.000009579681,0.000007715076,0.00001907813,0.00003558,0.00001758351],"domain_scores_gemma":[0.9999456,0.000007884819,0.00001271802,0.000004167937,0.00001183679,0.00001774429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001660149,0.00007751116,0.0005355992,0.0001775921,0.0000226974,0.0001327212,0.00001743307,0.0004282948,0.9906752,0.0001402172,0.000285721,0.007341042],"study_design_scores_gemma":[0.000256591,0.003846109,0.01359459,0.0001000572,0.0001729599,0.001500519,0.00006550759,0.002720784,0.9518019,0.0001458146,0.02576718,0.00002807479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555464,0.02639325,0.004125919,0.0006783509,0.0001610831,0.0003136141,0.001588235,0.0002800389,0.01091309],"genre_scores_gemma":[0.9683456,0.01681825,0.003896805,0.0002850083,0.00003036822,0.0001673518,0.002105279,0.00002928444,0.008321958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372606,"threshold_uncertainty_score":0.004239559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.035746818100829,"score_gpt":0.3065938225178945,"score_spread":0.2708470044170656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}