{"id":"W4375955901","doi":"10.7554/elife.84396","title":"Insights into cargo sorting by SNX32 and its role in neurite outgrowth","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"Science and Engineering Research Board; Department of Biotechnology, Ministry of Science and Technology, India; Indian Institute of Science","keywords":"Cell biology; Basigin; Neurite; Amphiphysin; Gene silencing; Transport protein; Biology; Sorting nexin; Immunoglobulin domain; HEK 293 cells; Mutant; Signal transducing adaptor protein; Receptor; Chemistry; Intracellular; Signal transduction; Endocytosis; Biochemistry; Endosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009148981,0.000396478,0.0001423686,0.0001424987,0.0001395135,0.0001738582,0.0001390423,0.0002513842,0.0007708233],"category_scores_gemma":[0.00003917609,0.00007919625,0.0001871477,0.00006995951,0.0001901892,0.0002578303,0.0002567774,0.0003526636,0.0003430025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002758616,"about_ca_system_score_gemma":0.0002009095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007352641,"about_ca_topic_score_gemma":0.0009306002,"domain_scores_codex":[0.9999601,0.000006436194,0.000002697094,0.000007171553,0.00001369132,0.000009893817],"domain_scores_gemma":[0.9999758,0.000002144476,0.000005993888,0.000002205853,0.000003643978,0.00001019883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003314221,0.000004045869,0.0002318756,0.00001730243,0.000001679165,0.00009768898,0.000009104228,0.00005978343,0.9988163,0.0001575829,0.000008337508,0.0005632404],"study_design_scores_gemma":[0.00001623428,0.0002259622,0.01910289,0.00002027471,0.00001816009,0.001460206,0.0001404034,0.00470746,0.9671481,0.0006128387,0.006537825,0.000009626494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948775,0.002194076,0.001689653,0.000153953,0.000009563459,0.000005710929,0.00009467248,0.00002441865,0.0009504858],"genre_scores_gemma":[0.9922502,0.002366424,0.002401799,0.00004649735,0.000005053445,0.000007871844,0.000243145,0.000008103681,0.00267087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007708233,"threshold_uncertainty_score":0.002578735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008623239105556952,"score_gpt":0.2463576993997788,"score_spread":0.2377344602942219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}