{"id":"W4375956000","doi":"10.1172/jci.insight.170270","title":"Continuous positive airway pressure increases CSF flow and glymphatic transport","year":2023,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cerebrospinal fluid and hydrocephalus","field":"Neuroscience","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; Yale University; National Institutes of Health; National Cancer Institute; National Center for Complementary and Integrative Health; Raymond and Beverly Sackler Institute for Biological, Physical and Engineering Sciences, Yale University; National Institute of General Medical Sciences; Cure Alzheimer's Fund","keywords":"Glymphatic system; Cerebrospinal fluid; Lymphatic system; Reabsorption; Medicine; Ventilation (architecture); Respiratory system; Anesthesia; Chemistry; Internal medicine; Pathology; Physics; Kidney","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183343,0.0003588769,0.000210388,0.0002062116,0.0001786129,0.0004446621,0.00021923,0.0003153464,0.0008581398],"category_scores_gemma":[0.0003204745,0.0001246946,0.0002830334,0.00008630866,0.000580871,0.0004798104,0.0003987795,0.0005500886,0.00008715159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314188,"about_ca_system_score_gemma":0.0004046591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004524243,"about_ca_topic_score_gemma":0.0004941662,"domain_scores_codex":[0.9998856,0.00001934993,0.000008236194,0.0000241734,0.00003856225,0.00002403068],"domain_scores_gemma":[0.9998468,0.00003544505,0.00006078116,0.0000113653,0.00001533778,0.00003021394],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002257202,0.0000329391,0.0004356915,0.00008334486,0.000007278566,0.00009846261,0.00002747866,0.000168716,0.9930323,0.0002127999,0.00006072275,0.005614513],"study_design_scores_gemma":[0.00006992318,0.002330901,0.01808813,0.00003457226,0.00004685685,0.000379679,0.0001215976,0.005376311,0.9685625,0.0005684658,0.004399931,0.00002097634],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878595,0.001979813,0.008335776,0.0003231186,0.00007627807,0.0000469301,0.0001375699,0.0001252141,0.001115668],"genre_scores_gemma":[0.9914424,0.001618228,0.006247676,0.00008881875,0.00003847097,0.00005076048,0.00007952358,0.00001897872,0.0004150584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008581398,"threshold_uncertainty_score":0.002870739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447022880245433,"score_gpt":0.2380718412430679,"score_spread":0.2236016124406136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}