{"id":"W4375956144","doi":"10.1038/s41467-023-38406-8","title":"Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institute on Alcohol Abuse and Alcoholism; University of California, San Diego; USC Norris Comprehensive Cancer Center; McGill University; McGill University Health Centre; University of Southern California; U.S. Department of Veterans Affairs; University of Kansas; National Institute of Diabetes and Digestive and Kidney Diseases; University of Tokyo; Icahn School of Medicine at Mount Sinai; U.S. Department of Health and Human Services","keywords":"Cancer research; Carcinogenesis; Hepatic stellate cell; Wnt signaling pathway; Gene knockdown; Biology; Tumor microenvironment; Hepatocellular carcinoma; Apoptosis; Signal transduction; Cell biology; Cancer; Endocrinology; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269039,0.0003744219,0.0002686449,0.0004057619,0.0002318933,0.0003386111,0.00006578047,0.0001787946,0.002767019],"category_scores_gemma":[0.00007844342,0.0001510828,0.0003714487,0.0001701671,0.0001636194,0.0001861276,0.0003322044,0.0003781951,0.0007337889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757909,"about_ca_system_score_gemma":0.0002105277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004144352,"about_ca_topic_score_gemma":0.0007681861,"domain_scores_codex":[0.9998535,0.00002891443,0.00001340717,0.000026968,0.00004256251,0.00003465476],"domain_scores_gemma":[0.9999195,0.000006038969,0.0000228577,0.00001112664,0.00001310042,0.00002725232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008671454,0.00000968258,0.000747767,0.00003101943,0.00001043967,0.0000965927,0.00001537932,0.0000387716,0.9973325,0.0001415613,0.00005677514,0.001432951],"study_design_scores_gemma":[0.00001964241,0.0002081371,0.01296674,0.000008304462,0.00002884613,0.0005437952,0.00007822206,0.0008277611,0.9781295,0.0001725963,0.007010611,0.000005968084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802371,0.004348977,0.009612362,0.0003074902,0.00005878289,0.00006606605,0.0007609978,0.0003959739,0.004212275],"genre_scores_gemma":[0.9920665,0.001387414,0.001168249,0.00005589785,0.00001291046,0.00003158858,0.0006002586,0.00002219344,0.004654955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002767019,"threshold_uncertainty_score":0.009256601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01691564464604129,"score_gpt":0.2806505074542378,"score_spread":0.2637348628081965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}