{"id":"W4376106594","doi":"10.1021/acs.jmedchem.2c01561","title":"Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI","year":2023,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; Lawson Health Research Institute; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; Natural Sciences and Engineering Research Council of Canada; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; National Institutes of Health; Ontario Institute for Cancer Research; Breast Cancer Society of Canada","keywords":"Chemistry; Gadolinium; MRI contrast agent; Chelation; In vitro; Magnetic resonance imaging; Pharmacokinetics; Nuclear magnetic resonance; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003139252,0.0005508282,0.0002936412,0.0002532018,0.0001531242,0.0002976728,0.000405401,0.0004186195,0.0005826012],"category_scores_gemma":[0.0002749717,0.0002835217,0.0001574989,0.0001605881,0.0001760809,0.0002802799,0.0002710913,0.0004712462,0.0002966956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003119685,"about_ca_system_score_gemma":0.0002511403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003885905,"about_ca_topic_score_gemma":0.0008536499,"domain_scores_codex":[0.9998639,0.00002581706,0.00001205043,0.0000340845,0.00004308866,0.00002107947],"domain_scores_gemma":[0.9998826,0.00001495414,0.00003551873,0.00001237018,0.00002649637,0.00002807481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002295863,0.00001105142,0.00004337207,0.0000382678,0.000003472604,0.00002512614,0.000009873339,0.0001407292,0.9965599,0.0001148837,0.00004128182,0.002989035],"study_design_scores_gemma":[0.0000159846,0.0002773035,0.0003418919,0.000006142274,0.00001139988,0.0002645854,0.000006923036,0.001069657,0.9936812,0.00003168347,0.004285818,0.00000746245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8560407,0.006519566,0.1300362,0.0004787357,0.00007888907,0.0007185505,0.0005486701,0.0006919109,0.004886796],"genre_scores_gemma":[0.8678975,0.003652594,0.1217813,0.0002833237,0.00002603342,0.0004250041,0.000922959,0.00007143181,0.004939903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005826012,"threshold_uncertainty_score":0.002263546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02181019261482374,"score_gpt":0.2706297266530164,"score_spread":0.2488195340381926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}