{"id":"W4376107568","doi":"10.1101/2023.05.09.540102","title":"Quantitative Comparison of Presenilin Protein Expression Reveals Greater Activity of PS2-γ-Secretase","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Dementia Australia","keywords":"Presenilin; Pathogenesis; Endogeny; Amyloid precursor protein secretase; Amyloid precursor protein; Enzyme; Biology; Cell biology; Chemistry; Biochemistry; Alzheimer's disease; Disease; Internal medicine; Immunology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003456986,0.0004615187,0.0002919262,0.0005941485,0.0001408983,0.0005031701,0.0001930406,0.0003953284,0.001414913],"category_scores_gemma":[0.0002617864,0.0001790082,0.000289299,0.0005330495,0.0002461009,0.0003160127,0.0001799185,0.0006672541,0.000455808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003672694,"about_ca_system_score_gemma":0.0001052693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969313,"about_ca_topic_score_gemma":0.0006837923,"domain_scores_codex":[0.999584,0.00005225349,0.00004105814,0.0001064149,0.0001625864,0.00005371594],"domain_scores_gemma":[0.9996092,0.000112616,0.00009335907,0.00004152004,0.00009173383,0.00005164286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002363743,0.000006668612,0.00006611181,0.0000160498,0.000003009818,0.000007821047,0.00001329618,0.00000885297,0.999645,0.0000150091,0.000006307636,0.0001883359],"study_design_scores_gemma":[0.000002274083,0.00006398204,0.005093374,0.000003125305,0.000009703304,0.0001038911,0.00002519978,0.0003367409,0.9936299,0.00001923595,0.0007085011,0.000004121408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784567,0.002659011,0.01526324,0.00007990134,0.0000502742,0.00005418577,0.001522134,0.0002295242,0.00168495],"genre_scores_gemma":[0.9649863,0.00211439,0.02086825,0.0001215496,0.00003120084,0.0001473072,0.003766408,0.0001470555,0.007817551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001414913,"threshold_uncertainty_score":0.004733384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07941604783612717,"score_gpt":0.3453287829371623,"score_spread":0.2659127351010352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}