{"id":"W4376113684","doi":"10.5152/tjg.2023.22527","title":"Mucosal Healing and Clinical Efficacy of Adalimumab in Small Intestinal Crohn’s Disease (SIMCHA Study): Final Results From a Prospective, Open-Label, Single-Arm Study","year":2023,"lang":"en","type":"article","venue":"The Turkish Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Dr. Falk Pharma; Genentech; Mitsubishi Tanabe Pharma Corporation; Kyowa Hakko Kirin; McGill University; McGill University Health Centre; Pfizer","keywords":"Medicine; Adalimumab; Internal medicine; Gastroenterology; Crohn's disease; Capsule endoscopy; Calprotectin; Prospective cohort study; Inflammatory bowel disease; Infliximab; C-reactive protein; Colonoscopy; Disease; Surgery; Colorectal cancer; Inflammation; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009056432,0.001060075,0.001850589,0.0004917643,0.0004376184,0.0009895698,0.000575399,0.000997159,0.001525087],"category_scores_gemma":[0.003151934,0.0004853998,0.001826911,0.0005001034,0.0008922016,0.000731273,0.0005709942,0.001061754,0.0004103233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003708783,"about_ca_system_score_gemma":0.0006121037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002772168,"about_ca_topic_score_gemma":0.0004928004,"domain_scores_codex":[0.9974873,0.001705932,0.0001687755,0.0002043298,0.0002831748,0.0001505717],"domain_scores_gemma":[0.9959825,0.001091743,0.001255708,0.0004591461,0.0003659267,0.0008449432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7497323,0.01533849,0.1794303,0.001018124,0.006632299,0.0002385805,0.0003592727,0.0005154375,0.0101294,0.00009430835,0.0007347873,0.0357768],"study_design_scores_gemma":[0.279798,0.2810076,0.4290752,0.0001455967,0.004578193,0.0005017171,0.0001670464,0.001014256,0.001945633,0.0001451071,0.001556005,0.00006575885],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959041,0.002339242,0.0002622154,0.00005661366,0.00002659664,0.0005385926,0.0003550018,0.00001520354,0.0005023931],"genre_scores_gemma":[0.996282,0.000884407,0.0006683044,0.0001643144,0.0001209058,0.0005379499,0.0009364496,0.000007392833,0.0003982498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009056432,"threshold_uncertainty_score":0.04789555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06271122840011223,"score_gpt":0.3350542738614553,"score_spread":0.272343045461343,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}