{"id":"W4376113926","doi":"10.1101/2023.05.08.539798","title":"EZH2 inhibition stimulates viral mimicry in resting splenic B cells","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"","keywords":"Biology; Ectopic expression; EZH2; Cell biology; Programmed cell death; Mutation; Molecular biology; Epigenetics; Cell culture; Genetics; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001520035,0.0002935166,0.0002560943,0.0001519564,0.00008820766,0.0002542495,0.0001810374,0.0001954774,0.002133877],"category_scores_gemma":[0.0000948606,0.00009614604,0.0002032761,0.000107654,0.0001392006,0.000109262,0.000217375,0.0007106345,0.0006135876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001890604,"about_ca_system_score_gemma":0.0001236028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003711265,"about_ca_topic_score_gemma":0.0005076308,"domain_scores_codex":[0.9998147,0.00003726313,0.00001621104,0.00002661758,0.00005255745,0.00005272673],"domain_scores_gemma":[0.9998877,0.0000255076,0.00002053761,0.00002152491,0.00001116065,0.0000335136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001254765,0.00002307469,0.00009128165,0.00001692396,0.000003794356,0.00002967458,0.000006224378,0.00004416725,0.9989808,0.00005027359,0.0000375719,0.0005906759],"study_design_scores_gemma":[0.00001001017,0.000162935,0.0009954309,0.000001273394,0.000003905037,0.00005773917,0.000006933799,0.000422136,0.9976625,0.00001787995,0.000658233,0.000001005716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945233,0.000977807,0.001593842,0.00008289416,0.00003315477,0.00002035671,0.0003732402,0.0001108476,0.002284583],"genre_scores_gemma":[0.9941564,0.0003446451,0.001401867,0.00005418035,0.0000145965,0.00002771847,0.0005690505,0.0000287652,0.003402833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002133877,"threshold_uncertainty_score":0.00713855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01758647043742394,"score_gpt":0.2396075842793702,"score_spread":0.2220211138419463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}