{"id":"W4376115779","doi":"10.3390/cancers15102683","title":"The Epigenetic Reader Methyl-CpG-Binding Protein 2 (MeCP2) Is an Emerging Oncogene in Cancer Biology","year":2023,"lang":"en","type":"review","venue":"Cancers","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Epigenetics; Oncogene; Biology; CpG site; DNA methylation; Computational biology; Genetics; Cancer; Cancer research; Phenotype; Gene; Gene expression; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003316115,0.0005054497,0.0006970079,0.0001571193,0.0002141283,0.00004587388,0.0006829471,0.0004326444,0.00004251444],"category_scores_gemma":[0.00005231014,0.0003980307,0.0002564315,0.0004942683,0.0001567518,0.000002924274,0.0002548386,0.0003167709,0.00003309218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004267987,"about_ca_system_score_gemma":0.001635734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004901828,"about_ca_topic_score_gemma":0.002002406,"domain_scores_codex":[0.9973247,0.0002478854,0.0006141203,0.0009561506,0.0001513507,0.0007058014],"domain_scores_gemma":[0.9988995,0.00002632013,0.000291726,0.0006045037,0.00004573089,0.0001322334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001697888,0.00001269034,0.00002107998,0.001411332,0.0002999065,0.000007391537,0.0001104798,0.00006606765,0.01981955,0.00002431452,0.001318523,0.9768917],"study_design_scores_gemma":[0.0001954427,0.000122972,0.00001079783,0.001088991,0.00009428328,0.000002845647,0.0001286636,0.00001097179,0.003562839,0.00005513416,0.994193,0.0005340977],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009917764,0.9878276,0.00001401689,0.00008364016,0.0006756412,0.001093044,0.0001609304,0.00001985934,0.0002074961],"genre_scores_gemma":[0.0004780286,0.9942639,0.00007631082,0.0001238709,0.0001285977,0.001806286,0.0003024236,0.0001493402,0.002671238],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9928744,"threshold_uncertainty_score":0.9998472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08975279017306761,"score_gpt":0.3842367317768192,"score_spread":0.2944839416037516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}