{"id":"W4376121868","doi":"10.1007/s40266-023-01032-6","title":"Impact of a Comprehensive Intervention Bundle Including the Drug Burden Index on Deprescribing Anticholinergic and Sedative Drugs in Older Acute Inpatients: A Non-randomised Controlled Before-and-After Pilot Study","year":2023,"lang":"en","type":"article","venue":"Drugs & Aging","topic":"Pharmaceutical Practices and Patient Outcomes","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Dalhousie University","funders":"National Health and Medical Research Council; Medical Research Council; NSW Ministry of Health; Dementia Australia; University of Sydney; Central Coast Local Health District; Royal North Shore Hospital","keywords":"Medicine; Anticholinergic; Deprescribing; Drug; Sedative; Pharmacotherapy; Intervention (counseling); Polypharmacy; Intensive care medicine; Anesthesia; Emergency medicine; Pharmacology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008649025,0.0002689235,0.0007482274,0.0004075065,0.0001253796,0.00005776107,0.0001008179,0.00003184918,0.00001858728],"category_scores_gemma":[0.0001778536,0.0001675371,0.0001624173,0.0004762803,0.00009310328,0.0002898074,0.0002722834,0.0004620065,0.00000478728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009230544,"about_ca_system_score_gemma":0.00002864669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323032,"about_ca_topic_score_gemma":0.00005605395,"domain_scores_codex":[0.9978983,0.0003723512,0.0006314145,0.0003611975,0.0003988939,0.0003378918],"domain_scores_gemma":[0.9980558,0.001173306,0.0003126563,0.0002190977,0.000120214,0.0001189657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02973465,0.001217788,0.8725227,0.0001609324,0.001189856,0.00004226945,0.09105685,0.0002393883,0.0005813898,0.000005709825,0.00002477485,0.003223757],"study_design_scores_gemma":[0.1359021,0.001992256,0.7904773,0.00088674,0.0006259048,0.000005459526,0.01249258,0.05729545,0.00007322412,0.00005166278,0.000006649639,0.0001906561],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959756,0.0001128729,0.00002232349,0.0005116507,0.000112777,0.00306209,0.00001065992,0.00003769674,0.0001543567],"genre_scores_gemma":[0.9993185,0.00005251504,0.00001247806,0.0002659062,0.00005513655,0.0001749245,0.00001937792,0.0000296126,0.00007154416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1061675,"threshold_uncertainty_score":0.6831963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05248098706810838,"score_gpt":0.395154338715658,"score_spread":0.3426733516475496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}