{"id":"W4376129250","doi":"10.33211/jnhpr.29","title":"Paradise Tree Extract (Simarouba glauca) Selectively Induces Cell Death, Enhances Efficacy of Common Chemotherapeutics and Reduces Their Toxicity in In-Vitro and In-Vivo Models of Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Health Product Research","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"University of Windsor","keywords":"In vivo; Cisplatin; Breast cancer; Apoptosis; Toxicity; Pharmacology; Cancer cell; Cancer; Cancer research; Combination therapy; Programmed cell death; Medicine; Chemotherapy; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001729293,0.0001435108,0.0004827686,0.0002957282,0.00004204129,0.00001156808,0.0002384847,0.00009349387,0.000001180872],"category_scores_gemma":[0.0001378633,0.0001027258,0.00004575415,0.0005698276,0.0002670263,0.00003139392,0.00012876,0.0007772305,2.822267e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001006227,"about_ca_system_score_gemma":0.0003809636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002233925,"about_ca_topic_score_gemma":0.0002273236,"domain_scores_codex":[0.998079,0.0003889566,0.0005427663,0.0002918922,0.0002841908,0.0004131739],"domain_scores_gemma":[0.9989552,0.0003282129,0.0002937957,0.0001209941,0.0002100015,0.00009180007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002271839,0.0003571571,0.006766835,0.0002036941,0.00001698891,0.000002880548,0.0003472493,0.00002697095,0.9738132,0.000001139613,0.0000315411,0.01616048],"study_design_scores_gemma":[0.0006608245,0.0003399519,0.1445792,0.0001387218,0.000001646056,0.00001634641,0.0001722842,0.0001669246,0.8530753,0.0007560019,0.00001251767,0.0000802782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848273,0.01324553,5.287031e-7,0.001537099,0.00003482306,0.0003003274,0.00002804986,0.000001985993,0.00002439324],"genre_scores_gemma":[0.9895399,0.01017354,0.0001122643,0.00003496781,0.0001020013,0.00000837379,0.000003411139,0.000009622007,0.00001591899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1378123,"threshold_uncertainty_score":0.4189036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0760743127853902,"score_gpt":0.395236432160695,"score_spread":0.3191621193753048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}