{"id":"W4376129250","doi":"10.33211/jnhpr.29","title":"Paradise Tree Extract (Simarouba glauca) Selectively Induces Cell Death, Enhances Efficacy of Common Chemotherapeutics and Reduces Their Toxicity in In-Vitro and In-Vivo Models of Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Journal of Natural Health Product Research","topic":"Phytochemical compounds biological activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"University of Windsor","keywords":"In vivo; Cisplatin; Breast cancer; Apoptosis; Toxicity; Pharmacology; Cancer cell; Cancer; Cancer research; Combination therapy; Programmed cell death; Medicine; Chemotherapy; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008132723,0.0002947553,0.0003013475,0.0003989449,0.0001089108,0.0001214427,0.0001402602,0.0001916943,0.001253542],"category_scores_gemma":[0.0000776146,0.00007934123,0.000268626,0.0002017334,0.0001202553,0.0001562007,0.0001273918,0.0004428732,0.0002595304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008615736,"about_ca_system_score_gemma":0.0001113035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003274532,"about_ca_topic_score_gemma":0.0009014038,"domain_scores_codex":[0.9999428,0.00001052182,0.000003928506,0.00001076857,0.00001954702,0.00001246232],"domain_scores_gemma":[0.9999373,0.00001098496,0.00001930583,0.000007901419,0.00001064173,0.0000139387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000294493,0.0001156493,0.0001929672,0.00008512109,0.00001185234,0.00006239362,0.00001023737,0.00004973605,0.9966027,0.000024385,0.00006237007,0.002488167],"study_design_scores_gemma":[0.00006033394,0.002073793,0.01038122,0.00001828427,0.0000601326,0.0004708968,0.00003138878,0.0003564885,0.9831234,0.00004003385,0.003377252,0.000006713477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907327,0.004235341,0.00171699,0.0001644676,0.00003419442,0.00004753174,0.0004344819,0.0001197023,0.002514519],"genre_scores_gemma":[0.9922998,0.002186186,0.001724033,0.0001004178,0.00002155943,0.00002753609,0.0007721466,0.00002298034,0.00284543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253542,"threshold_uncertainty_score":0.004193544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0760743127853902,"score_gpt":0.395236432160695,"score_spread":0.3191621193753048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}