{"id":"W4376132812","doi":"10.1038/s41467-023-38390-z","title":"Confinement of unliganded EGFR by tetraspanin nanodomains gates EGFR ligand binding and signaling","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Dalhousie University; Hospital for Sick Children; Toronto Metropolitan University","funders":"National Institute of General Medical Sciences; Medical Research Council; Canadian Institutes of Health Research; National Health and Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Government of Canada","keywords":"Tetraspanin; Ectodomain; Ligand (biochemistry); Cell biology; Epidermal growth factor receptor; Biophysics; Chemistry; Receptor; Biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007662913,0.0001174353,0.0001941239,0.00008994697,0.0001574094,0.0003013495,0.0002545687,0.0002234304,0.0004293046],"category_scores_gemma":[0.0001116138,0.0001295682,0.0001662863,0.00008740609,0.0002329508,0.0002825298,0.0002776032,0.0003332111,0.0001616868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004805807,"about_ca_system_score_gemma":0.0002223848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006221629,"about_ca_topic_score_gemma":0.0009804878,"domain_scores_codex":[0.9998997,0.000008659249,0.000005757587,0.00002354556,0.00003280109,0.00002957051],"domain_scores_gemma":[0.9999429,0.00001062155,0.0000174108,0.000007560798,0.000007087488,0.00001449813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002367208,0.000007694682,0.0000992202,0.00001004589,0.000001567387,0.00001652507,0.000008843021,0.000206901,0.9984119,0.0003414599,0.00002571642,0.0008464676],"study_design_scores_gemma":[0.000007290042,0.00006562121,0.00154247,0.000003904133,0.000005402754,0.00005405349,0.0000204941,0.008260981,0.9884829,0.0001550152,0.001396589,0.000005244375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925678,0.0004373204,0.005801418,0.00005510032,0.00001812699,0.000007615445,0.00004249,0.00007777271,0.0009924966],"genre_scores_gemma":[0.996538,0.0003413098,0.002310388,0.00004545779,0.000004738974,0.00001328232,0.00004571891,0.00001349928,0.0006876081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006221629,"threshold_uncertainty_score":0.003486872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03451073365499922,"score_gpt":0.3517177691731347,"score_spread":0.3172070355181355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}