{"id":"W4376133442","doi":"10.1093/nar/gkad375","title":"OnTarget: <i>in silico</i> design of MiniPromoters for targeted delivery of expression","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Weston Brain Institute; Genome Canada","keywords":"Biology; Enhancer; Computational biology; Promoter; In silico; Chromatin; Bioinformatics; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007903092,0.00008123292,0.0001432,0.0001821435,0.00003051819,0.000004359861,0.0002227039,0.0001227807,0.00001534201],"category_scores_gemma":[0.0001709689,0.00007957412,0.00006330208,0.0002999125,0.00007823218,0.000002631202,0.0001298386,0.00008861389,0.000003862056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001185041,"about_ca_system_score_gemma":0.0000693802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003192939,"about_ca_topic_score_gemma":0.000008192115,"domain_scores_codex":[0.9989333,0.00007619261,0.0002139403,0.0002322977,0.0002254161,0.0003188445],"domain_scores_gemma":[0.9994314,0.00007914359,0.00002781043,0.0002676928,0.000142691,0.0000512597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091161,0.00004148051,0.0009657929,0.00009608585,0.00001204452,0.000001602633,0.0001675957,0.002172024,0.9906208,0.000004276281,0.003995384,0.001713828],"study_design_scores_gemma":[0.0005408212,0.0004472146,0.002711436,0.00004228458,0.000002204222,6.037544e-7,0.0002325708,0.002452562,0.9913752,0.00004647524,0.002071904,0.00007671745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925827,0.00040443,0.006375201,0.0000390254,0.00004839013,0.0004048326,0.00002499526,0.000008495191,0.0001118745],"genre_scores_gemma":[0.9948714,0.0002117986,0.00447316,0.000006265287,0.00004167989,0.00004828725,0.00005002399,0.00002381822,0.0002735436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002288668,"threshold_uncertainty_score":0.3244939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04367789731131333,"score_gpt":0.3655873714563466,"score_spread":0.3219094741450332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}