{"id":"W4376133686","doi":"10.1084/jem.20220509","title":"Obesity alters monocyte developmental trajectories to enhance metastasis","year":2023,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; Astellas Pharma; Terry Fox Research Institute; EMD Serono; Susan G. Komen; Canada Foundation for Innovation; Incyte; Regeneron Pharmaceuticals; McGill University; Canada Research Chairs; Pfizer; Susan G. Komen for the Cure; AstraZeneca; Amgen; Breast Cancer Research Foundation","keywords":"CXCL2; Metastasis; Cancer research; Monocyte; Medicine; Cancer; Immunology; Myeloid; Chemokine; Lung cancer; Inflammation; Mass cytometry; Biology; Internal medicine; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388203,0.0001216051,0.0001576759,0.0003175245,0.0001383298,0.0003793768,0.00006799462,0.0002237786,0.001103795],"category_scores_gemma":[0.0001543188,0.0001680953,0.0001521341,0.0001792893,0.0001260909,0.0001472726,0.0002395724,0.0005558406,0.0002881347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002080374,"about_ca_system_score_gemma":0.0002943835,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006822691,"about_ca_topic_score_gemma":0.001492433,"domain_scores_codex":[0.9998986,0.00002170767,0.000005398933,0.00001959068,0.00001628769,0.00003841091],"domain_scores_gemma":[0.9999025,0.00001132022,0.00002506526,0.000007275835,0.000016661,0.00003713031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001915912,0.000110449,0.02142897,0.00008626192,0.0000191771,0.0005299374,0.0002102575,0.0001834168,0.9573018,0.001738941,0.0004342429,0.01604054],"study_design_scores_gemma":[0.0001654733,0.002503828,0.6010535,0.0001637748,0.0001389101,0.002975172,0.001232728,0.003286037,0.3577964,0.002391985,0.02822502,0.00006711223],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934039,0.002491007,0.001721822,0.0001665994,0.00002382137,0.00002477689,0.0004297907,0.00003355109,0.001704822],"genre_scores_gemma":[0.993663,0.001954747,0.001551709,0.0001456993,0.00001474828,0.00005323403,0.0002879419,0.00001501833,0.002313907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001103795,"threshold_uncertainty_score":0.003692567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02685778737766806,"score_gpt":0.3244412774957167,"score_spread":0.2975834901180486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}