{"id":"W4376134070","doi":"10.1186/s13578-023-01024-4","title":"ISG15 suppresses ovulation and female fertility by ISGylating ADAMTS1","year":2023,"lang":"en","type":"article","venue":"Cell & Bioscience","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"Science and Technology Service Network Plan; Jiangsu Provincial Key Research and Development Program; Key Technologies Research and Development Program of Anhui Province","keywords":"Fertility; Ovulation; ISG15; Gynecology; Biology; Andrology; Demography; Medicine; Pregnancy; Population; Sociology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001743657,0.0003151558,0.0002145972,0.0003130065,0.0001384066,0.000246578,0.0002380993,0.0002673396,0.001980305],"category_scores_gemma":[0.0001003936,0.0001119337,0.0003178359,0.000160871,0.000417849,0.0001463625,0.0002070973,0.0004745486,0.0002500642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003078129,"about_ca_system_score_gemma":0.0002171559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000327573,"about_ca_topic_score_gemma":0.0005585268,"domain_scores_codex":[0.9998099,0.00003726416,0.00002039899,0.00003420347,0.0000478301,0.00005041181],"domain_scores_gemma":[0.9998665,0.000009223678,0.00005361513,0.00001845961,0.000008575631,0.00004359286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002546385,0.00004354935,0.0008932772,0.00004625443,0.00001619171,0.0000753135,0.00001315614,0.00008503145,0.9960944,0.0002573869,0.00009956658,0.002121317],"study_design_scores_gemma":[0.00002934884,0.0004491867,0.008026494,0.000008111698,0.0000280008,0.0002252116,0.00003087013,0.0006197359,0.9870676,0.0001002449,0.003411686,0.000003504845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938813,0.001507427,0.00209517,0.0002127724,0.00007587747,0.00002572071,0.00024144,0.0001024145,0.001857892],"genre_scores_gemma":[0.9964142,0.000393152,0.0008893065,0.0000659765,0.00001028781,0.00001619926,0.0001950028,0.00001350716,0.002002279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001980305,"threshold_uncertainty_score":0.006624758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507874257407486,"score_gpt":0.2509775374343349,"score_spread":0.2358987948602601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}