{"id":"W4376134693","doi":"10.1038/s41593-023-01326-3","title":"ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain","year":2023,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Victoria","funders":"Junta de Andalucía; Barncancerfonden; Sigrid Juséliuksen Säätiö; Ministerio de Ciencia e Innovación; University of Victoria; Vetenskapsrådet; Hjärnfonden; Radiumhemmets Forskningsfonder; Cancerfonden; Karolinska Institutet; European Commission; Svenska Kulturfonden; Academy of Finland; Swedish Cancer Foundation; Åke Wiberg Stiftelse; Fonds de Recherche du Québec - Santé; Wenner-Gren Foundation","keywords":"Microglia; Neuroscience; Biology; Hippocampus; Forebrain; Basal forebrain; Cholinergic; Arginase; Long-term potentiation; Cholinergic neuron; Central nervous system; Immunology; Inflammation; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001857317,0.0004412668,0.000206795,0.0008494293,0.0002103003,0.0004291082,0.0001816161,0.0003339731,0.001180293],"category_scores_gemma":[0.00009951486,0.000221271,0.0002311502,0.0001605507,0.0002582269,0.0002932389,0.00023477,0.0006403063,0.0005279786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729821,"about_ca_system_score_gemma":0.0001462396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373846,"about_ca_topic_score_gemma":0.0008948517,"domain_scores_codex":[0.9998342,0.00001445792,0.00001363301,0.00004175961,0.00004272802,0.00005328838],"domain_scores_gemma":[0.9998088,0.00001577811,0.00008177066,0.00001534845,0.00002181633,0.00005651543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078894,0.00001755742,0.0004823886,0.00001372142,0.000002488405,0.00006549354,0.00002328546,0.00002363943,0.998168,0.00007122353,0.00002154202,0.001002705],"study_design_scores_gemma":[0.00001306199,0.0002322768,0.02237593,0.00001905434,0.00002586765,0.0007370002,0.0000896936,0.0005116334,0.9734274,0.0001886325,0.002369353,0.00001004655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924621,0.001771944,0.003184974,0.00008964196,0.00002003462,0.00001986734,0.0008056352,0.0001517192,0.001494088],"genre_scores_gemma":[0.9836104,0.001928891,0.004980244,0.00007182959,0.00001631147,0.00006861862,0.0009632038,0.00009278221,0.008267857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180293,"threshold_uncertainty_score":0.00394845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01509763400759255,"score_gpt":0.2402251086448587,"score_spread":0.2251274746372662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}