{"id":"W4376134916","doi":"10.1016/j.celrep.2023.112500","title":"Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Vitamin K Research Studies","field":"Nursing","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Institut de Recherche Clinique De Montréal; Canada Research Chairs; University of Alberta; National Institutes of Health; Diabetes Canada; Diabète Québec","keywords":"Endoplasmic reticulum; Unfolded protein response; Cell biology; Secretion; Carboxylation; Chemistry; Flux (metallurgy); Context (archaeology); Proteostasis; Pyruvate carboxylase; Vitamin; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788737,0.000230088,0.0003537045,0.0002735344,0.0002688768,0.0004759026,0.0002538242,0.0003685087,0.0007907618],"category_scores_gemma":[0.0002105102,0.0001472341,0.0002678776,0.0002192954,0.000400499,0.0003579133,0.0002785552,0.000482204,0.0001901367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003594423,"about_ca_system_score_gemma":0.0002174418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154041,"about_ca_topic_score_gemma":0.001132119,"domain_scores_codex":[0.999876,0.00002246007,0.00001248893,0.00003688926,0.00002225775,0.00002982922],"domain_scores_gemma":[0.9999028,0.00001193424,0.00002398544,0.00001266456,0.00002205815,0.00002649097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004355512,0.00001595182,0.0005142895,0.00004240772,0.000009124874,0.00005735353,0.00003957176,0.00001938184,0.9977435,0.00006808192,0.0000356813,0.001019022],"study_design_scores_gemma":[0.000131284,0.0004212957,0.04413978,0.00002503266,0.00008527585,0.0006107764,0.0003129016,0.0007089964,0.9477026,0.0004686059,0.00537378,0.00001954253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844556,0.01066144,0.002550876,0.0004932926,0.00006818564,0.00002462404,0.0002018558,0.00006546101,0.001478707],"genre_scores_gemma":[0.9935333,0.003589971,0.001336202,0.0001031078,0.00001381864,0.00002350168,0.000121269,0.00001475153,0.001264073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001154041,"threshold_uncertainty_score":0.002645433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211447209881239,"score_gpt":0.2791812436858226,"score_spread":0.2570667715870102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}