{"id":"W4376167335","doi":"10.17615/jtnt-qj24","title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Leukemia and Lymphoma Research; National Health and Medical Research Council; José Carreras Leukämie-Stiftung; U.S. Public Health Service; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; U.S. Department of Veterans Affairs; Compagnia di San Paolo; European Commission; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; Division of Cancer Prevention, National Cancer Institute; Health Research Board; Stockholms Läns Landsting; University of Pittsburgh; University of Southern California; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Cancer Research UK; Ohio State University; Instituto de Salud Carlos III; Wake Forest University; Yale University; Karolinska Institutet; Utah State University; Leukemia and Lymphoma Society; Utah Department of Health; Brigham and Women's Hospital; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; Cancer Council Victoria","keywords":"Gene; Immunity; Biology; Genome-wide association study; Genetics; Immune dysregulation; Genome; Genetic association; Immunology; Immune system; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002189702,0.0005367934,0.0008083424,0.001654511,0.0005581609,0.001091987,0.0004670773,0.0006093311,0.001884766],"category_scores_gemma":[0.004136057,0.0003179334,0.002054151,0.002383359,0.0003745251,0.0002979582,0.0007158963,0.0006172595,0.0001639148],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002905462,"about_ca_system_score_gemma":0.0003110117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004535854,"about_ca_topic_score_gemma":0.0056737,"domain_scores_codex":[0.9983686,0.0005040404,0.000146311,0.0006041414,0.0002488552,0.0001280922],"domain_scores_gemma":[0.9977348,0.001143582,0.0005147526,0.000322502,0.0001737163,0.000110619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001480535,0.00003450278,0.95241,0.0003908658,0.01456192,0.000487053,0.0001290635,0.0006380164,0.010609,0.0001501747,0.000585295,0.01852359],"study_design_scores_gemma":[0.0001086134,0.00019865,0.9850419,0.00006673776,0.009508588,0.0008942328,0.0001001428,0.0006221074,0.001291704,0.0003971645,0.001755483,0.0000146278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9600875,0.03402433,0.002996993,0.0005290577,0.0001036203,0.00001455219,0.001206272,0.000100379,0.0009373417],"genre_scores_gemma":[0.9956238,0.003018172,0.0005649013,0.00009268539,0.0000527903,0.000008867695,0.0004237589,0.00001400105,0.0002010281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004535854,"threshold_uncertainty_score":0.01158035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02450020797029051,"score_gpt":0.2679189159826498,"score_spread":0.2434187080123593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}