{"id":"W4376167335","doi":"10.17615/jtnt-qj24","title":"Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia","year":2020,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Cancer Council NSW; Medical Research Council; University of Texas MD Anderson Cancer Center; Institut National Du Cancer; Centers for Disease Control and Prevention; National Institutes of Health; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Leukemia and Lymphoma Research; National Health and Medical Research Council; José Carreras Leukämie-Stiftung; U.S. Public Health Service; University at Buffalo; Regione Autonoma della Sardegna; Associazione Italiana per la Ricerca sul Cancro; Fondation de France; Generalitat de Catalunya; Canadian Institutes of Health Research; Bundesamt für Strahlenschutz; MedStar Health Research Institute; Cancerfonden; U.S. Department of Veterans Affairs; Compagnia di San Paolo; European Commission; Ministerio de Economía y Competitividad; Bundesministerium für Bildung und Forschung; Division of Cancer Epidemiology and Genetics, National Cancer Institute; Huntsman Cancer Institute; Division of Cancer Prevention, National Cancer Institute; Health Research Board; Stockholms Läns Landsting; University of Pittsburgh; University of Southern California; Memorial Sloan-Kettering Cancer Center; Wellcome Trust; Cancer Research UK; Ohio State University; Instituto de Salud Carlos III; Wake Forest University; Yale University; Karolinska Institutet; Utah State University; Leukemia and Lymphoma Society; Utah Department of Health; Brigham and Women's Hospital; U.S. Department of Health and Human Services; University of California, San Francisco; Michael Smith Health Research BC; Cancer Council Victoria","keywords":"Gene; Immunity; Biology; Genome-wide association study; Genetics; Immune dysregulation; Genome; Genetic association; Immunology; Immune system; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003114465,0.0001842181,0.0006369472,0.0003682252,0.00006536082,0.00005654592,0.0002375348,0.0001927356,0.0003343322],"category_scores_gemma":[0.0009797023,0.0001727511,0.0002062145,0.002211114,0.0001305773,0.0004668004,0.0001893067,0.0001967649,0.00004422438],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.03076968,"about_ca_system_score_gemma":0.01254505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001252639,"about_ca_topic_score_gemma":0.0001270628,"domain_scores_codex":[0.9980105,0.0001325541,0.000580425,0.0003323803,0.0005479915,0.0003961636],"domain_scores_gemma":[0.9982966,0.0007177131,0.0002471714,0.0004367771,0.0001387939,0.0001629926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001253823,0.0001403995,0.8964595,0.001578906,0.003329012,0.00007506328,0.005186956,0.02589457,0.05438401,0.007625096,0.000849695,0.003223033],"study_design_scores_gemma":[0.01496821,0.0004653434,0.7230934,0.00009177414,0.001176784,0.000006289625,0.0005159435,0.1409245,0.1111421,0.00496031,0.00223161,0.0004237294],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928192,0.00315736,0.0007100432,0.001717648,0.00002384808,0.0004092725,0.00002083362,0.00009212599,0.001049671],"genre_scores_gemma":[0.9977867,0.0001068158,0.0009289059,0.0003362509,0.0001434619,0.00002552551,0.0003366074,0.00002799634,0.0003077205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1733661,"threshold_uncertainty_score":0.9930529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02450020797029051,"score_gpt":0.2679189159826498,"score_spread":0.2434187080123593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}