{"id":"W4376223485","doi":"10.1016/j.mucimm.2023.05.004","title":"IL-18 is required for the TH1-adaptation of TREG cells and the selective suppression of TH17 responses in acute and chronic infections","year":2023,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Canada Research Chairs; McGill University","keywords":"Immunology; Immune system; Biology; CXCR3; Acquired immune system; Interleukin 17; Chemokine; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002001659,0.0003374175,0.0003207401,0.0002342372,0.0001917378,0.0004005227,0.0002060548,0.0002484792,0.001270168],"category_scores_gemma":[0.000246327,0.0001960688,0.0002590905,0.000108394,0.0003196909,0.0002539261,0.0002597076,0.0008489524,0.0005475931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001901619,"about_ca_system_score_gemma":0.0002183282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001897717,"about_ca_topic_score_gemma":0.0002431732,"domain_scores_codex":[0.9997172,0.00004262112,0.00003483485,0.00005634697,0.00004858256,0.0001003652],"domain_scores_gemma":[0.9996312,0.00002847772,0.0001743708,0.00003445327,0.00003544518,0.00009620262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003196014,0.00003831393,0.001823961,0.00006871916,0.000006478092,0.000272005,0.00003609443,0.00006497122,0.994947,0.0001386436,0.00009919341,0.002184917],"study_design_scores_gemma":[0.0001625943,0.001134642,0.1139864,0.00008834706,0.00008597742,0.004051951,0.0003010868,0.001706575,0.8613049,0.0006866269,0.01646134,0.00002939856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993817,0.002393714,0.002082418,0.0001089358,0.00006669384,0.00002231647,0.000332045,0.0001209113,0.001055934],"genre_scores_gemma":[0.99672,0.000774346,0.001219307,0.00006923197,0.00003824498,0.00003165967,0.0003203254,0.00003406101,0.0007927276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270168,"threshold_uncertainty_score":0.004249156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01227590293292864,"score_gpt":0.2666026666888295,"score_spread":0.2543267637559009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}