{"id":"W4376223895","doi":"10.1053/j.gastro.2023.04.032","title":"ALKBH5 Drives Immune Suppression Via Targeting AXIN2 to Promote Colorectal Cancer and Is a Target for Boosting Immunotherapy","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Natural Science Foundation of China; Cornell University","keywords":"Biology; Cancer research; Immunology; Wnt signaling pathway; Immune system; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001633634,0.0002316263,0.0001150669,0.0001612377,0.0001308209,0.000203675,0.0001456567,0.0002119543,0.002135172],"category_scores_gemma":[0.00006604251,0.0001263564,0.0002085875,0.00008639891,0.00020375,0.0001531734,0.0001729361,0.0005364004,0.0003005017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000299969,"about_ca_system_score_gemma":0.0001787344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002632243,"about_ca_topic_score_gemma":0.0006871697,"domain_scores_codex":[0.9998841,0.00001385711,0.000008625389,0.00002820536,0.00003625355,0.00002892486],"domain_scores_gemma":[0.9999424,0.000008000716,0.00002055778,0.00000633544,0.000005001614,0.00001777215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008829012,0.00001903957,0.0003527847,0.00004342045,0.000005328157,0.00003677309,0.000009060726,0.00009085208,0.9974394,0.0002240039,0.00006465021,0.001626279],"study_design_scores_gemma":[0.00003272202,0.0004358398,0.00462694,0.000009004538,0.0000250622,0.0003623895,0.00003253829,0.001404012,0.9881054,0.0001263502,0.004835353,0.000004278626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890169,0.002473944,0.005017617,0.0002459624,0.00005253003,0.00004337542,0.0003118165,0.0001291144,0.002708619],"genre_scores_gemma":[0.9945757,0.0006021109,0.001657665,0.00008712657,0.000009497427,0.00002478103,0.0002760192,0.00001148489,0.002755591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002135172,"threshold_uncertainty_score":0.007142842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007489391216358819,"score_gpt":0.2576890221640455,"score_spread":0.2501996309476867,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}