{"id":"W4376224029","doi":"10.1152/physrev.00001.2023","title":"The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health","year":2023,"lang":"en","type":"review","venue":"Physiological Reviews","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Research Institute; Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Foundation; Government of Canada","keywords":"Placentation; Placenta; Trophoblast; Biology; Epigenetics; Epigenome; Stem cell; Embryonic stem cell; Bioinformatics; Fetus; Pregnancy; Neuroscience; Physiology; Cell biology; DNA methylation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006830853,0.0004447531,0.0004471801,0.0007374415,0.0002630675,0.0008469792,0.00049237,0.0007087097,0.002094899],"category_scores_gemma":[0.0003658456,0.0002314233,0.0004374614,0.0004705193,0.0009539602,0.0008140424,0.0006993718,0.001794619,0.0005153374],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005679462,"about_ca_system_score_gemma":0.0005227634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005139822,"about_ca_topic_score_gemma":0.0007678798,"domain_scores_codex":[0.9998185,0.00006087945,0.00001580428,0.00003980516,0.00004805473,0.00001691282],"domain_scores_gemma":[0.999882,0.00004992669,0.00001981839,0.00001165802,0.00001907904,0.00001754682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002752875,0.00007248419,0.001020569,0.005911618,0.000133481,0.001236036,0.001118497,0.001751475,0.510171,0.1550139,0.01553128,0.3077644],"study_design_scores_gemma":[0.00001794898,0.0002374796,0.002732212,0.0007307344,0.0001408782,0.002501266,0.0003460394,0.00135956,0.07385077,0.02363158,0.8944059,0.00004566374],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0183115,0.8608554,0.08108172,0.008283894,0.001970743,0.00007607838,0.0005316582,0.000447614,0.02844146],"genre_scores_gemma":[0.1186871,0.8379047,0.02638636,0.00173226,0.0009473903,0.000162817,0.0005385303,0.0001157932,0.01352504],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002094899,"threshold_uncertainty_score":0.007008135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2120141601897347,"score_gpt":0.3949224408506253,"score_spread":0.1829082806608906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}