{"id":"W4376225150","doi":"10.1007/s00726-023-03273-6","title":"P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents","year":2023,"lang":"en","type":"article","venue":"Amino Acids","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Courtois Foundation","keywords":"Histamine; Antihistamine; Histamine H2 receptor; Cimetidine; Histamine receptor; Histamine H4 receptor; Diamine oxidase; Desloratadine; Histamine H1 receptor; Histamine N-methyltransferase; Pharmacology; Chemistry; Histaminergic; Receptor; Histamine H3 receptor; Biology; Biochemistry; Antagonist; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445266,0.0003548607,0.0002045436,0.0002005088,0.0001112027,0.0002211619,0.0002010182,0.0002840382,0.001149965],"category_scores_gemma":[0.0001023319,0.0001108972,0.0002192737,0.0001467044,0.0001139567,0.000194373,0.0001351933,0.0003589494,0.0004377742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000187712,"about_ca_system_score_gemma":0.00009206119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003906705,"about_ca_topic_score_gemma":0.0007461495,"domain_scores_codex":[0.9998978,0.00001254689,0.00001099019,0.000021805,0.00003885547,0.00001799497],"domain_scores_gemma":[0.9999321,0.00001156364,0.00001612685,0.000008305437,0.00001909789,0.0000128767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002054975,0.00001368763,0.000105487,0.00002087192,0.000002766261,0.00003106709,0.000002480291,0.00001091563,0.9990417,0.00001254116,0.000007376224,0.0007305621],"study_design_scores_gemma":[0.000006704797,0.0005230743,0.002910593,0.00000535688,0.00002976134,0.0001679062,0.00001759416,0.0004208511,0.9943797,0.00002292287,0.001512901,0.000002657747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973927,0.003994664,0.0178535,0.0001202192,0.00006943938,0.0002390655,0.0008836663,0.00009638433,0.00281597],"genre_scores_gemma":[0.9643427,0.004376836,0.02504959,0.00009525742,0.00002382537,0.0001823228,0.001303832,0.00002875218,0.004596871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001149965,"threshold_uncertainty_score":0.003847003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03741272476429148,"score_gpt":0.2786408807144776,"score_spread":0.2412281559501861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}