{"id":"W4376225150","doi":"10.1007/s00726-023-03273-6","title":"P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents","year":2023,"lang":"en","type":"article","venue":"Amino Acids","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Courtois Foundation","keywords":"Histamine; Antihistamine; Histamine H2 receptor; Cimetidine; Histamine receptor; Histamine H4 receptor; Diamine oxidase; Desloratadine; Histamine H1 receptor; Histamine N-methyltransferase; Pharmacology; Chemistry; Histaminergic; Receptor; Histamine H3 receptor; Biology; Biochemistry; Antagonist; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004189936,0.0004439447,0.0005492533,0.0003368281,0.0002926367,0.00005242177,0.0004105442,0.0002914488,0.001387742],"category_scores_gemma":[0.00007123275,0.0004157271,0.0001173585,0.0005049398,0.0004382109,0.0001087189,0.0004734077,0.0003989168,0.002467902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006260962,"about_ca_system_score_gemma":0.00004444077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005636247,"about_ca_topic_score_gemma":0.000005123173,"domain_scores_codex":[0.9972889,0.0002658023,0.0004999326,0.0009034821,0.0001529022,0.0008890018],"domain_scores_gemma":[0.9989501,0.0001373646,0.0001101201,0.0005168605,0.0001024096,0.0001830953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002654197,0.0003193724,0.0006459438,0.0001112586,0.0001147256,0.00002702823,0.0009040578,0.00001474651,0.9442132,0.0002258607,0.04678629,0.006372098],"study_design_scores_gemma":[0.003781113,0.0005247446,0.01606316,0.00004411408,0.0001536051,0.00005368581,0.000355055,0.0004985131,0.224939,0.00002457736,0.7528198,0.0007426495],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905128,0.0008034619,0.0003290476,0.0004305882,0.001688945,0.0006263299,0.0001598609,0.0002648825,0.00518411],"genre_scores_gemma":[0.9456739,0.0003671011,0.0005867938,0.0007153701,0.0001383889,0.0001051307,0.0006089598,0.0000749661,0.05172943],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7192742,"threshold_uncertainty_score":0.9998295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03741272476429148,"score_gpt":0.2786408807144776,"score_spread":0.2412281559501861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}