{"id":"W4376225588","doi":"10.1007/s00125-023-05925-4","title":"Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis","year":2023,"lang":"en","type":"article","venue":"Diabetologia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Ontario Ministry of Research and Innovation; NIHR Imperial Biomedical Research Centre; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Mutuelle Générale de l'Education Nationale; U.S. Department of Veterans Affairs; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Imperial College London; Generalitat de Catalunya; Karolinska Institutet; University of Cambridge; ZonMw; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Pelotonia; Umeå Universitet; Centres de Recerca de Catalunya; Génome Québec; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; McGill University; Women's Health Initiative; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund International; U.S. Department of Health and Human Services; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Instituto de Salud Carlos III; Ohio State University; National Center for Chronic Disease Prevention and Health Promotion; School of Public Health, Imperial College London; Deutsche Krebshilfe; KWF Kankerbestrijding; Cancer Research UK; American Cancer Society; Ministerstvo Zdravotnictví Ceské Republiky; European Commission","keywords":"Drug; Mendelian inheritance; Medicine; Human physiology; Internal medicine; Mendelian randomization; Pharmacology; Genetics; Oncology; Endocrinology; Biology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006166051,0.0001119291,0.0003010059,0.0001282867,0.00007720781,0.000008234379,0.00008743659,0.0001386737,0.00002076245],"category_scores_gemma":[0.0005187813,0.00009941334,0.0001093282,0.0003819576,0.00006931405,0.000001990064,0.00006767747,0.00005811732,0.000002867816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001197822,"about_ca_system_score_gemma":0.00003778966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001354776,"about_ca_topic_score_gemma":0.000152852,"domain_scores_codex":[0.9989488,0.0001610024,0.0002957482,0.0002956735,0.00008030792,0.0002184891],"domain_scores_gemma":[0.9993896,0.00007802788,0.0002032566,0.0001892103,0.00008869946,0.00005119876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00004719334,0.00001591021,0.9444582,0.00001295607,0.0007114207,2.520862e-7,0.0001096869,0.004944659,0.04642666,0.00002918918,0.0003687575,0.002875047],"study_design_scores_gemma":[0.0009729966,0.00007396885,0.9410692,0.000003885589,0.0004660968,2.44786e-7,0.00009868295,0.01800997,0.03784543,0.0006689247,0.0006326949,0.000157929],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954136,0.001185589,0.00270441,0.000223871,0.00007149197,0.0001834618,0.00006025172,0.00002125697,0.0001360908],"genre_scores_gemma":[0.9939862,0.003630055,0.001705005,0.00004412478,0.00004781648,0.00007551316,0.0002851905,0.000009631711,0.0002164328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01306531,"threshold_uncertainty_score":0.4053958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00790174785308245,"score_gpt":0.2575669160602075,"score_spread":0.2496651682071251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}