{"id":"W4376225588","doi":"10.1007/s00125-023-05925-4","title":"Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis","year":2023,"lang":"en","type":"article","venue":"Diabetologia","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Ontario Ministry of Research and Innovation; NIHR Imperial Biomedical Research Centre; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Mutuelle Générale de l'Education Nationale; U.S. Department of Veterans Affairs; Grantová Agentura České Republiky; Herzfelder'sche Familienstiftung; Institut Gustave-Roussy; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Stockholms Läns Landsting; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Imperial College London; Generalitat de Catalunya; Karolinska Institutet; University of Cambridge; ZonMw; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Pelotonia; Umeå Universitet; Centres de Recerca de Catalunya; Génome Québec; Bundesministerium für Bildung und Forschung; Swedish Cancer Foundation; Johns Hopkins University; Centre International de Recherche sur le Cancer; Ligue Contre le Cancer; McGill University; Women's Health Initiative; Univerzita Karlova v Praze; Deutsches Krebsforschungszentrum; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; World Cancer Research Fund International; U.S. Department of Health and Human Services; World Health Organization; Xarxa de Bancs de Tumors de Catalunya; Xunta de Galicia; Instituto de Salud Carlos III; Ohio State University; National Center for Chronic Disease Prevention and Health Promotion; School of Public Health, Imperial College London; Deutsche Krebshilfe; KWF Kankerbestrijding; Cancer Research UK; American Cancer Society; Ministerstvo Zdravotnictví Ceské Republiky; European Commission","keywords":"Drug; Mendelian inheritance; Medicine; Human physiology; Internal medicine; Mendelian randomization; Pharmacology; Genetics; Oncology; Endocrinology; Biology; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06498039,0.002496782,0.00419631,0.003381044,0.001068544,0.00155671,0.003813894,0.002167284,0.008446633],"category_scores_gemma":[0.08473899,0.00112014,0.007487757,0.003410743,0.002109839,0.001031354,0.001890605,0.002446169,0.0007881356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001033365,"about_ca_system_score_gemma":0.001517745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004392956,"about_ca_topic_score_gemma":0.001961506,"domain_scores_codex":[0.8972887,0.08140922,0.002859083,0.01246697,0.004500449,0.001475538],"domain_scores_gemma":[0.952018,0.03501572,0.00299489,0.008496964,0.0009778597,0.0004966093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.05488551,0.001549252,0.5220465,0.001827469,0.07691301,0.008582844,0.001901031,0.1063766,0.01381102,0.07667767,0.008751513,0.1266777],"study_design_scores_gemma":[0.01006522,0.008388503,0.1512526,0.0003254613,0.02616152,0.003597097,0.0003812625,0.7520583,0.004145237,0.03405448,0.009193067,0.0003773191],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4275999,0.001348487,0.5603707,0.0005445268,0.0002772161,0.005177211,0.001817,0.001041213,0.001823693],"genre_scores_gemma":[0.8438731,0.0003205961,0.1454733,0.0002660206,0.00008027112,0.006496903,0.001127831,0.0001706277,0.00219127],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.06498039,"threshold_uncertainty_score":0.3436533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00790174785308245,"score_gpt":0.2575669160602075,"score_spread":0.2496651682071251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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