{"id":"W4376255913","doi":"10.1101/2023.05.11.540368","title":"PI(3,4,5)P3 allosteric regulation of repressor activator protein 1 controls antigenic variation in trypanosomes","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Islamic Development Bank; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; Repressor; Gene silencing; Activator (genetics); Antigenic variation; Cell biology; Rap1; Gene; Transcription (linguistics); Genetics; Transcription factor; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007115694,0.0001376743,0.0001108975,0.0001333124,0.0001389614,0.0003085486,0.000170749,0.0001532428,0.001565833],"category_scores_gemma":[0.0001200752,0.00009260021,0.0001103255,0.00008110681,0.0002441434,0.0001407039,0.0002216912,0.0002735526,0.0004370389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000459944,"about_ca_system_score_gemma":0.0001600205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009823766,"about_ca_topic_score_gemma":0.001243861,"domain_scores_codex":[0.9999347,0.000009622454,0.000003011103,0.00002033421,0.00001114039,0.00002128731],"domain_scores_gemma":[0.9999431,0.00001160268,0.00001671678,0.000005435078,0.000006178258,0.00001688276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008934129,0.000009551482,0.0002966266,0.00001114298,0.00000137732,0.00002235072,0.00001205333,0.00006763724,0.9985942,0.0002134484,0.00004717087,0.0006350432],"study_design_scores_gemma":[0.00005574884,0.0001513065,0.03767819,0.000008822128,0.0000127869,0.0001761549,0.00009522193,0.01012622,0.9485786,0.0005886351,0.002516014,0.0000122909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957521,0.0005451438,0.001816973,0.00009225391,0.00001233456,0.000006028396,0.0001803745,0.00009176691,0.001502963],"genre_scores_gemma":[0.9981861,0.0001285862,0.0003810407,0.00002543191,0.000003312071,0.000007818097,0.0001265431,0.0000171851,0.001124014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565833,"threshold_uncertainty_score":0.005238295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03082334253903952,"score_gpt":0.2729755881655054,"score_spread":0.2421522456264659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}