{"id":"W4376504845","doi":"10.1101/2023.05.12.540513","title":"Fluctuation of lysosomal protein degradation in neural stem cells of postnatal mouse brain","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Japan Society for the Promotion of Science; Japan Agency for Medical Research and Development","keywords":"Neural stem cell; Autophagy; Dentate gyrus; Hippocampal formation; Cell biology; Lysosome; Immunostaining; Stem cell; Protein degradation; Biology; Neuroscience; Intracellular; Chemistry; Biochemistry; Immunohistochemistry; Immunology; Enzyme; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002781603,0.0003494489,0.0003664461,0.001138493,0.0001716432,0.0003430718,0.000216201,0.0003788022,0.001333096],"category_scores_gemma":[0.0001237246,0.0002448455,0.0003456092,0.0003874889,0.0003515091,0.0002672883,0.000226446,0.0007219291,0.0005393688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000308113,"about_ca_system_score_gemma":0.0002579395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009362659,"about_ca_topic_score_gemma":0.001422321,"domain_scores_codex":[0.9997587,0.00001484167,0.0000252085,0.00008497554,0.00007427449,0.00004204011],"domain_scores_gemma":[0.999793,0.00003538846,0.00005748143,0.00002097175,0.00002929308,0.00006394732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009454035,0.00001925149,0.0005469607,0.00002786469,0.000007756483,0.00008245555,0.00005982167,0.00003482329,0.9974832,0.0001871437,0.00004521433,0.00141107],"study_design_scores_gemma":[0.00001544591,0.0001345246,0.008984195,0.000008514566,0.00002240783,0.0002377864,0.00005927802,0.0005261343,0.9880242,0.0001575211,0.001823016,0.000006991545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977161,0.00491178,0.01098524,0.0002153843,0.00006692783,0.00006215408,0.002656891,0.0003412562,0.003599321],"genre_scores_gemma":[0.9658421,0.003026716,0.01203197,0.0001938931,0.00002768017,0.0002588556,0.003690053,0.0002237057,0.01470515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001333096,"threshold_uncertainty_score":0.00445962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02063065761069315,"score_gpt":0.2426982535207208,"score_spread":0.2220675959100277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}